Non-redundant compendium of human ncRNA genes in GeneCards
Non-redundant compendium of human ncRNA genes in GeneCards
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DOI：
10.1093/bioinformatics/bts676
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发表时间：
2013-01-15
期刊：
影响因子：
5.8
通讯作者：
Lancet, Doron
中科院分区：
文献类型：
--
作者：
Belinky, Frida;Bahir, Iris;Lancet, Doron
动机：非编码RNA（ncRNA）基因在人类基因组中的重要性越来越被认可。然而，有没有全面的非冗余数据库，为所有这些人类genes.Results：我们利用了有效的平台GeneCards，人类基因纲要，连同电源fRNAdb和其他主要来源，明智地统一所有ncRNA基因条目可从15个不同的主要来源。基于采用基因组坐标的算法将重叠条目聚类到统一位置。这使得GeneCards的相关条目范围增加了近5倍，产生了约80，000个人类非冗余ncRNA，属于14个类别。这种定期更新的数据结构中的“大统一”将有助于未来的ncRNA研究。
Motivation: Non-coding RNA (ncRNA) genes are increasingly acknowledged for their importance in the human genome. However, there is no comprehensive non-redundant database for all such human genes.Results: We leveraged the effective platform of GeneCards, the human gene compendium, together with the power of fRNAdb and additional primary sources, to judiciously unify all ncRNA gene entries obtainable from 15 different primary sources. Overlapping entries were clustered to unified locations based on an algorithm employing genomic coordinates. This allowed GeneCards' gamut of relevant entries to rise similar to 5-fold, resulting in similar to 80 000 human non-redundant ncRNAs, belonging to 14 classes. Such 'grand unification' within a regularly updated data structure will assist future ncRNA research.