Bacterial membrane vesicles (MVs): Novel tools as nature- and nano-carriers for immunogenic antigen, enzyme support, and drug delivery
Bacterial membrane vesicles (MVs): Novel tools as nature- and nano-carriers for immunogenic antigen, enzyme support, and drug delivery
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细菌膜囊泡（MV）：作为免疫原性抗原、酶支持和药物输送的天然载体和纳米载体的新工具
DOI：
10.1007/s00253-016-7916-7
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发表时间：
2016
影响因子：
5
通讯作者：
Kunihiko Watanabe
中科院分区：
文献类型：
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作者：
高橋 敬祐;井元 瞭介;川上 春佳;加藤 崚介;林 幹朗;竹野 誠記;池田 正人;Kunihiko Watanabe
众所周知，细菌细胞以萌发的方式从细胞表面产生膜泡(MVS)，但MV生物发生的详细机制尚不清楚。MV不是真正的细胞，因为它们被观察到大小在20到300纳米之间，但具有接近亚细胞隔室的结构。在某种意义上，含有生物和细胞物质的MVS的结构和它们的行为看起来与病毒相似。由于这些科学事实，已经提出并报道了几个使用MVS作为一种有前景的工具的潜在应用。本文介绍了MVS在生物技术中应用前景广阔的几个突出例子。
It is becoming well-known that bacterial cells produce membrane vesicles (MVs) from the cell surface in a budding manner, whereas the detailed mechanisms of MV biogenesis remain unclear. MVs are not authentic cells, since they are observed to be between 20 and 300 nm in size but have a structure close to the subcellular compartments. In a sense, the structure of MVs containing biogenic and cellular substances and their behavior look similar to those of viruses. Due to these scientific facts, several potent applications employing MVs as a promising tool have been proposed and reported. This review introduces a few outstanding examples for promising applications of MVs to biotechnology.