Immunomodulatory effects of a traditional Chinese medicine with potential antiviral activity: A self-control study
Immunomodulatory effects of a traditional Chinese medicine with potential antiviral activity: A self-control study
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DOI：
10.1142/s0192415x0600359x
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发表时间：
2006-01-01
影响因子：
5.7
通讯作者：
Lam, CWK
中科院分区：
文献类型：
--
作者：
Poon, PMK;Wong, CK;Lam, CWK
2003年春季，香港爆发严重急性呼吸系统综合症（SARS），中医药一直被用于预防和治疗。我们研究了从两种草药配方（桑菊饮和玉屏风散）中提取的用于治疗发热性疾病的创新中药方案的免疫调节作用。37名健康志愿者每天口服中药方案14天。分别于第0、15、29天采集外周静脉血进行血液学、生化和免疫学检查，包括血淋巴细胞亚群和血浆辅助性T淋巴细胞1型和2型细胞因子及受体的测定。3个月后，23名志愿者参加了一项对照研究，没有中医治疗，进行相同时间的血液检查。两名志愿者在第2天因头痛和头晕退出研究。所有其他人都保持良好，没有任何副作用。除了T淋巴细胞CD 4/CD 8比值从第0天的1.31 +/- 0.50（平均值+/- SD）显著增加到第15天的1.41 +/- 0.63（p < 0.02），并在第29天降低到1.32 +/- 0.47（p < 0.05）外，没有参与者的血液测试结果显示出显著变化。在对照研究中，CD 4/CD 8比值没有变化。CD 4/CD 8比值的一过性升高可能是由于TCM摄入所致。我们推测，创新中药的管理可能具有有益的免疫调节作用，预防病毒感染，包括SARS。
Traditional Chinese medicine (TCM) has been used for prevention and treatment of severe acute respiratory syndrome (SARS) in Hong Kong during the outbreak in spring 2003. We investigated the immunomodulating effects of an innovative TCM regimen derived from two herbal formulas (Sang Ju Yin and Yu Ping Feng San) for treating febrile diseases. Thirty-seven healthy volunteers were given the oral TCM regimen daily for 14 days. Peripheral venous blood samples were taken on days 0, 15 and 29 for hematology, biochemistry and immunology tests, including the measurement of blood lymphocyte subsets and plasma T-helper lymphocyte types 1 and 2 cytokines and receptor. After 3 months, 23 of the volunteers participated in a control study without TCM treatment for the same time course of blood tests. Two volunteers withdrew on day 2, due to headache and dizziness. All others remained well without any side effects. No participants showed significant changes in their blood test results, except that the T-lymphocyte CD4/CD8 ratio increased significantly from 1.31 +/- 0.50 (mean +/- SD) on day 0 to 1.41 +/- 0.63 on day 15 (p < 0.02), and reduced to 1.32 +/- 0.47 on day 29 (p < 0.05). In the control study, there were no changes in the CD4/CD8 ratio. The transient increase in CD4/CD8 ratio was likely due to the TCM intake. We postulate that the administration of the innovative TCM may have beneficial immunomodulatory effects for preventing viral infections including SARS.