Pluripotent Stem Cells: Current Understanding and Future Directions.
Pluripotent Stem Cells: Current Understanding and Future Directions.
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DOI：
10.1155/2016/9451492
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发表时间：
2016
影响因子：
4.3
通讯作者：
Cobellis G
中科院分区：
文献类型：
--
作者：
Romito A;Cobellis G
多能干细胞具有进行自我更新和产生身体组织的所有细胞的能力。然而，这个定义最近已经复杂的存在不同的细胞状态，显示这些功能。在这里，我们提供了来自早期小鼠和人类胚胎的多能细胞系家族的详细概述，并将其与诱导多能干细胞进行比较。这些细胞的共同和独特的特征被报道为多能性的额外标志，提供了多能干细胞的综合方案。
Pluripotent stem cells have the ability to undergo self-renewal and to give rise to all cells of the tissues of the body. However, this definition has been recently complicated by the existence of distinct cellular states that display these features. Here, we provide a detailed overview of the family of pluripotent cell lines derived from early mouse and human embryos and compare them with induced pluripotent stem cells. Shared and distinct features of these cells are reported as additional hallmark of pluripotency, offering a comprehensive scenario of pluripotent stem cells.