IMMINENT OOCYTE EXHAUSTION AND REDUCED FOLLICULAR RECRUITMENT MARK THE TRANSITION TO ACYCLICITY IN AGING C57BL/6J MICE
IMMINENT OOCYTE EXHAUSTION AND REDUCED FOLLICULAR RECRUITMENT MARK THE TRANSITION TO ACYCLICITY IN AGING C57BL/6J MICE
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DOI：
10.1095/biolreprod28.2.255
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发表时间：
1983-01-01
影响因子：
3.6
通讯作者：
FINCH, CE
中科院分区：
文献类型：
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作者：
GOSDEN, RG;LAING, SC;FINCH, CE
对C57BL/6J小鼠老化卵巢的定量细胞学分析表明，在排卵失败的平均年龄13-14个月时，原始卵泡和生长卵泡的数量几乎耗尽。平均而言，这个年龄段的无排卵动物的卵泡数量是仍在排卵的同类动物的一半。显然，卵泡衰竭是导致衰老过程中卵巢周期性丧失的一个因素。然而，两组卵泡数量的显著重叠表明，其他因素，可能是卵巢外的，也影响排卵功能的丧失。尽管老年动物卵巢中为生长而招募的卵泡数量要少得多，但周期排出的卵子数量一般在年轻个体的范围内。在中等大小的卵泡中观察到的形态闭锁的发生率的减少可能解释了排卵的恒定性是如何在卵巢的整个周期生命中几乎保持的。
Quantitative cytological analyses of aging C57BL/6J mouse ovaries revealed that the populations of primordial and growing follicles were nearly exhausted by 13-14 mo., the average age of ovulatory failure. Anovulatory animals of this age had, on the average, half the follicle number of their counterparts which were still ovulating. Apparently follicular depletion is a factor which contributes to the loss of ovarian cyclicity during aging. However, the considerable overlap of follicle number between the 2 groups suggests that other, possibly extraovarian, factors also influence the loss of ovulatory function. Although the numbers of follicles recruited for growth was much lower in ovaries from old cycling animals, the number of ova shed cyclically was generally within the range of younger individuals. The observed reduction in incidence of morphological atresia among medium-sized follicles may explain how ovulatory constancy is maintained virtually throughout the cyclical life of the ovary.