Role of sendai virus fusion-glycoprotein in target cell susceptibility to cytotoxic T cells
Role of sendai virus fusion-glycoprotein in target cell susceptibility to cytotoxic T cells
复制标题
仙台病毒融合糖蛋白在靶细胞对细胞毒性T细胞敏感性中的作用
作者：
K. Sugamura;K. Shimizu;D. Zarling;F. Bach
在小鼠体内，细胞毒性T淋巴细胞(CTL)是在体外产生的抗病毒感染的同基因细胞1-4。杀伤的特异性要求靶细胞同时具有病毒基因产物(S)和H-2K和/或与效应细胞5相同的H-2K和/或D基因产物。包被非传染性(紫外线灭活)仙台病毒的靶细胞也被同源病毒特异性CTL 6特异性裂解。我们在这里表明，它主要是仙台病毒包膜的融合糖蛋白，它是在被紫外线灭活的仙台病毒包裹的细胞上形成靶抗原所必需的。
IN mice, cytotoxic T lymphocytes (CTLs) are generatedin vivoorin vitroagainst virally-infected syngeneic cells1–4. The specificity of killing requires that the target cells possess both viral gene product(s) and H–2K and/or D gene products which are identical to those on the effector cells5. Target cells coated with non-infectious (ultraviolet-inactivated) Sendai virus are also specifically lysed by syngeneic virus-specific CTLs6. We show here that it is primarily the fusion glycoprotein of the Sendai virus envelope which is essential for the formation of the target antigen on cells coated with ultraviolet-inactivated Sendai virus.