Cholinergic control of the cerebral vasculature in humans
Cholinergic control of the cerebral vasculature in humans
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DOI：
10.1113/jphysiol.2012.245100
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发表时间：
2012-12-01
影响因子：
5.5
通讯作者：
Taylor, J. Andrew
中科院分区：
文献类型：
--
作者：
Hamner, J. W.;Tan, Can Ozan;Taylor, J. Andrew
尽管越来越多的证据表明自主神经系统参与脑血流量的调节，胆碱能血管舒张对脑自动调节的具体贡献仍然未知。我们研究了脑和前臂血流反应增强动脉压振荡与胆碱能阻滞。振荡下体负压施加在6个频率从0.03到0.08赫兹在9名健康受试者和没有胆碱能阻滞通过格隆溴铵。胆碱能阻滞增加了除0.03 Hz外所有频率下动脉压和脑血流之间的交叉频谱相干性，并增加了0.05 Hz以上频率下的传递函数增益。相比之下，压力和前臂流量之间的增益仅在低于0.06 Hz的频率下增加。这些数据表明，胆碱能系统在脑自动调节中起着积极而独特的作用。影响的频率范围和幅度与交感神经阻滞非常相似，表明两种反射之间可能存在平衡，以最有效地响应压力的上升和下降。这些发现可能对脑血管疾病状态下血管自主控制功能障碍的作用有影响。
Despite growing evidence of autonomic nervous system involvement in the regulation of cerebral blood flow, the specific contribution of cholinergic vasodilatation to cerebral autoregulation remains unknown. We examined cerebral and forearm blood flow responses to augmented arterial pressure oscillations with and without cholinergic blockade. Oscillatory lower body negative pressure was applied at six frequencies from 0.03 to 0.08 Hz in nine healthy subjects with and without cholinergic blockade via glycopyrrolate. Cholinergic blockade increased cross-spectral coherence between arterial pressure and cerebral flow at all frequencies except 0.03 Hz and increased the transfer function gain at frequencies above 0.05 Hz. In contrast, gain between pressure and forearm flow increased only at frequencies below 0.06 Hz. These data demonstrate that the cholinergic system plays an active and unique role in cerebral autoregulation. The frequency region and magnitude of effect is very similar to what has been seen with sympathetic blockade, indicating a possible balance between the two reflexes to most effectively respond to rising and falling pressure. These findings might have implications for the role of dysfunction in autonomic control of the vasculature in cerebrovascular disease states.