Refractive Index Measurement of the Crystalline Lens in Vivo.
Refractive Index Measurement of the Crystalline Lens in Vivo.
复制标题
体内晶状体的折射率测量。
DOI：
10.1097/opx.0000000000002081
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
He,JiC
中科院分区：
文献类型：
--
作者：
He,JiC
目的测定人体内晶状体的折射率一直是一个难题。本研究旨在利用前段光学相干断层扫描（AS-OCT）系统结合Scheimpflug成像系统测量体内晶状体的折射率。方法研制了一种射线可追踪的Scheimpflug成像系统，并将其集成到AS-OCT系统中。理论研究表明，这两种系统的结合为同时测量透镜的折射率和厚度提供了独特的解决方案。测量了7名受试者的平均透镜折射率（nav）和透镜形状。结果不同受试者的晶状体沿中央射线的nav变化范围为1.383 ~ 1.419。透镜在透镜直径上的折射率函数因对象而异。调节后的眼睛晶状体nav增大。透镜的厚度和轮廓也被确定。结论晶状体的折射率在不同的眼睛之间有很大的差异，不仅沿中央射线路径，而且沿晶状体直径的折射率函数也有很大的差异。配备有可追踪光线的激光成像的AS-OCT可用于测试人眼体内晶状体的折射率。
PurposeAccessing the refractive index of crystalline lenses in the human eye in vivo has long been a challenge. This study aimed to measure the refractive index of a lens in vivo using an anterior segment optical coherence tomography (AS-OCT) system combined with a Scheimpflug imaging system.MethodA ray-traceable Scheimpflug imaging was developed and integrated into an AS-OCT system. A theoretical study revealed that the combination of these two systems provides a unique solution for simultaneously measuring the refractive index and the thickness of the lens. The average lens refractive index along the ray pathway (N av) and lens shape were measured for seven subjects.ResultsThe lens N av along the central ray varies from 1.383 to 1.419 between subjects. The lens refractive index function across the lens diameter varies from subject to subject. The lens N av increases for accommodated eyes. The thicknesses and profiles of the lenses are also determined.ConclusionsThe lens refractive index varies substantially from individual eye to individual eye, not only along the central ray pathway but also for the lens refractive index function across the lens diameter. Ray-traceable Scheimpflug imaging-equipped AS-OCT is useful for testing the refractive index of lenses in the human eye in vivo.