Elevated levels of opioid growth factor in the plasma of patients with pancreatic cancer.
Elevated levels of opioid growth factor in the plasma of patients with pancreatic cancer.
复制标题
胰腺癌患者血浆中阿片类生长因子的水平升高。
DOI：
10.1097/00006676-200008000-00009
复制
发表时间：
2000
期刊：
影响因子：
2.9
通讯作者：
Zagon,IS
中科院分区：
文献类型：
--
作者：
Smith,JP;Conter,RL;Demers,TM;McLaughlin,PJ;Zagon,IS
阿片生长因子（Opioid growth factor， OGF，[Met 5]-脑啡肽）是调节人胰腺癌生长的内源性肽。为了评估胰腺癌患者是否有血浆OGF水平的改变，从15例组织学证实的胰腺腺癌患者中获得空腹血液样本。45名其他恶性肿瘤患者，20名急性胰腺炎患者和30名年龄匹配的无癌症患者作为对照人群。根据放射免疫测定法，胰腺癌患者的OGF值比对照组高出7.3倍。其他恶性肿瘤患者、急性胰腺炎患者和非癌症患者的OGF值没有差异。OGF对胰腺癌的敏感性和特异性均高于CA 19-9和CEA。这些数据表明胰腺癌与血浆OGF水平显著升高相关，并提示该肽可作为筛查胰腺癌的有用诊断工具。
Opioid growth factor (OGF,[Met 5]-enkephalin) is an endogenous peptide that regulates the growth of human pancreatic cancer. To evaluate whether human subjects with pancreatic cancer have alterations in plasma levels of OGF, fasting blood samples were obtained from 15 patients with histologically confirmed pancreatic adenocarcinoma. Forty-five subjects with other malignancies, 20 patients with acute pancreatitis, and 30 aged-matched patients without cancer served as control populations. Individuals with pancreatic cancer had OGF values, as determined by radioimmunoassay, that were up to 7.3-fold greater than control subjects. No differences were found between OGF values obtained from patients with other malignancies, acute pancreatitis, or subjects without cancer. The sensitivity and specificity of OGF for pancreatic cancer were greater than either CA 19-9 or CEA. These data indicate that pancreatic cancer is associated with a marked increase in plasma OGF levels and suggest that this peptide may serve as a useful diagnostic tool in the screening for this disease.