Long-term impact of breast-feeding on body weight and glucose tolerance in children of diabetic mothers - Role of the late neonatal period and early infancy
Long-term impact of breast-feeding on body weight and glucose tolerance in children of diabetic mothers - Role of the late neonatal period and early infancy
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DOI：
10.2337/diacare.28.6.1457
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发表时间：
2005-06-01
期刊：
影响因子：
16.2
通讯作者：
Plagemann, A
中科院分区：
文献类型：
--
作者：
Rodekamp, E;Harder, T;Plagemann, A
目的-糖尿病母亲（ODM）的后代发生超重和糖耐量受损（IGT）的风险增加。最近，我们观察到早期新生儿摄入糖尿病母亲（DBM）的母乳可能会剂量依赖性地增加儿童期超重的风险。在这里，我们调查了在新生儿晚期和婴儿早期DBM摄入是否也影响ODM中后来的脂肪形成和糖尿病形成风险。研究设计和方法-总共评估了112名ODM在新生儿晚期DBM摄入的影响（第2 - 4周新生儿）和婴儿早期对儿童早期相对体重（RBW）和葡萄糖耐量的影响。喂养与儿童期RBW增加相关（P = 0.011）。母乳喂养的ODM有超重的风险增加（比值比1.98 [95%CI 1.12-3.50]）。母乳喂养持续时间也与儿童RBW（P = 0.004）和口服葡萄糖耐量试验期间120分钟血糖（P = 0.022）呈正相关。然而，调整新生儿早期摄入的DBM量，即，出生后第1周，消除了所有这些与晚期新生儿母乳喂养及其持续时间的关系。有趣的是，没有观察到产妇血糖之间的关系，在中期的第三个三个月和outcome.CONCLUSIONS -无论是晚新生儿DBM摄入量，也不是母乳喂养的持续时间有一个独立的影响，对儿童的超重或IGT的风险在ODM。因此，出生后第1周似乎是ODM中通过摄入母体“糖尿病”母乳进行营养规划的关键窗口。
OBJECTIVE - Offspring of diabetic mothers (ODM) are at increased risk of developing overweight and impaired glucose tolerance (IGT). Recently, we observed that early neonatal ingestion of breast milk from diabetic mothers (DBM) may dose-dependently increase the risk of over-weight in childhood. Here, we investigate whether DBM intake during the late neonatal period and early infancy also influences later adipogenic and diabetogenic risk in ODM.RESEARCH DESIGN AND METHODS - A total of 112 ODM were evaluated for influence of DBM ingestion during the late neonatal period (2nd-4th neonatal week) and early infancy on relative body weight (RBW) and glucose tolerance in early childhood.RESULTS - Exclusive breast-feeding was associated with increased childhood RBW (P = 0.011). Breast-fed ODM had an increased risk of overweight (odds ratio 1.98 [95% CI 1.12-3.50]). Breast-feeding duration was also positively related to childhood RBW (P = 0.004) and 120-min blood glucose during an oral glucose tolerance test (P = 0.022). However, adjustment for the DBM volume ingested during the early neonatal period, i.e., 1st week of life, eliminated all these relations with late neonatal breast-feeding and its duration. Interestingly, no relationship was observed between maternal blood glucose in the middle of the third trimester and the outcome.CONCLUSIONS - Neither late neonatal DBM intake nor the duration of breast-feeding has an independent influence on childhood risk of overweight or IGT in ODM. Therefore, the 1st week of life appears to be the critical window for nutritional programming in ODM by ingestion of maternal "diabetic" breast milk.