Exercise-induced neuroplasticity in human Parkinson's disease: What is the evidence telling us?
Exercise-induced neuroplasticity in human Parkinson's disease: What is the evidence telling us?
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DOI：
10.1016/j.parkreldis.2015.09.030
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发表时间：
2016-01-01
影响因子：
4.1
通讯作者：
Sanjak, Mohammed
中科院分区：
文献类型：
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作者：
Hirsch, Mark A.;Iyer, Sanjay S.;Sanjak, Mohammed
虽然运动和帕金森病的动物模型推动了这一领域的发展，但很少有研究涉及人类帕金森病运动诱导的神经可塑性。方法：作为促进人类PD运动诱导神经可塑性国际合作的第一步，我们提出了8项人类PD研究（发表于2008年至2015年）的数据，涉及144名患有不同疾病严重程度的PD成人（Hoehn和Yahr阶段1至3），采用各种实验（例如随机对照试验）和准实验设计，研究认知和身体活动对PD大脑结构或功能的影响。我们关注干预诱导的最大皮质运动兴奋性增加、运动诱导的基于体素的灰质体积变化和运动诱导的脑源性神经营养因子（BDNF）血清水平增加的可塑性机制。最后，展望了运动诱导的PD神经可塑性的国际合作研究前景。结论：越来越多的证据表明，运动引发了人类PD大脑中一些与可塑性相关的事件，包括皮质运动兴奋、灰质体积的增加和减少以及BDNF水平的变化。(C) 2015 Elsevier Ltd.版权所有。
Introduction: While animal models of exercise and PD have pushed the field forward, few studies have addressed exercise-induced neuroplasticity in human PD.Method: As a first step toward promoting greater international collaboration on exercise-induced neuroplasticity in human PD, we present data on 8 human PD studies (published between 2008 and 2015) with 144 adults with PD of varying disease severity (Hoehn and Yahr stage 1 to stage 3), using various experimental (e.g., randomized controlled trial) and quasi-experimental designs on the effects of cognitive and physical activity on brain structure or function in PD. We focus on plasticity mechanisms of intervention-induced increases in maximal corticomotor excitability, exercise-induced changes in voxel-based gray matter volume changes and increases in exercise-induced serum levels of brain derived neurotrophic factor (BDNF). Finally, we provide a future perspective for promoting international, collaborative research on exercise-induced neuroplasticity in human PD.Conclusion: An emerging body of evidence suggests exercise triggers several plasticity related events in the human PD brain including corticomotor excitation, increases and decreases in gray matter volume and changes in BDNF levels. (C) 2015 Elsevier Ltd. All rights reserved.