Volatile organic compounds and risk of asthma and allergy: a systematic review.
Volatile organic compounds and risk of asthma and allergy: a systematic review.
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DOI：
10.1183/09059180.00000714
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发表时间：
2015-03
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挥发性有机化合物（VOCs）是普遍存在的生活污染物。它们在哮喘/过敏发展和加重中的作用尚不确定。本系统评价调查了家庭VOC暴露是否会增加哮喘和过敏性疾病发生和/或加重的风险。我们系统地检索了11个数据库和3个试验数据库，并联系了一个国际专家小组，以确定已发表和未发表的实验和流行病学研究。确定了8455项潜在相关研究;重复删除后删除了852篇论文，剩下7603篇独特论文进行了筛选。其中，278例进行了详细审查，53例符合纳入标准。对纳入研究的批判性评价表明，总体上缺乏高质量的证据，并且在这一知识体系中存在很大的偏倚风险。芳香族化合物（即苯、甲苯和二甲苯）和甲醛是研究的主要挥发性有机化合物类别，与哮喘和过敏的发生和加重有关。大约同样数量的研究报告说，接触会增加风险，而接触不会产生任何有害影响。现有的证据表明，国内挥发性有机化合物暴露的风险发展和/或加剧哮喘和过敏是质量差，不一致。现在需要进行前瞻性的，最好是实验性的研究，调查减少/消除VOC暴露的影响，以产生更明确的证据基础，为政策和临床审议提供信息，这些政策和临床审议与目前相当大的人群管理有关，这些人群要么有患哮喘/过敏症的风险，要么患有已确定的疾病。VOC与哮喘或过敏的发生或加重相关的调查表明需要进行新的研究http://ow.ly/wEJ19
Volatile organic compounds (VOCs) are ubiquitous domestic pollutants. Their role in asthma/allergy development and exacerbations is uncertain. This systematic review investigated whether domestic VOC exposure increases the risk of developing and/or exacerbating asthma and allergic disorders. We systematically searched 11 databases and three trial repositories, and contacted an international panel of experts to identify published and unpublished experimental and epidemiological studies. 8455 potentially relevant studies were identified; 852 papers were removed after de-duplication, leaving 7603 unique papers that were screened. Of these, 278 were reviewed in detail and 53 satisfied the inclusion criteria. Critical appraisal of the included studies indicated an overall lack of high-quality evidence and substantial risk of bias in this body of knowledge. Aromatics (i.e. benzenes, toluenes and xylenes) and formaldehyde were the main VOC classes studied, both in relation to the development and exacerbations of asthma and allergy. Approximately equal numbers of studies reported that exposure increased risks and that exposure was not associated with any detrimental effects. The available evidence implicating domestic VOC exposure in the risk of developing and/or exacerbating asthma and allergy is of poor quality and inconsistent. Prospective, preferably experimental studies, investigating the impact of reducing/eliminating exposure to VOC, are now needed in order to generate a more definitive evidence base to inform policy and clinical deliberations in relation to the management of the now substantial sections of the population who are either at risk of developing asthma/allergy or living with established disease. Investigation of VOCs in relation to developing or exacerbating asthma or allergy indicates new studies are required http://ow.ly/wEJ19