Structural and genetic analysis of the BldB protein of Streptomyces coelicolor
Structural and genetic analysis of the BldB protein of Streptomyces coelicolor
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DOI：
10.1128/jb.184.15.4270-4276.2002
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发表时间：
2002-08-01
影响因子：
3.2
通讯作者：
Nodwell, J
中科院分区：
文献类型：
--
作者：
Eccleston, M;Ali, RA;Nodwell, J
我们已经证明天蓝色链霉菌的bldB基因是气生菌丝形成和抗生素合成所必需的。我们还发现，BldB形成了一个更高级的复合物（最有可能是二聚体），氨基酸残基20至78是重要的这种相互作用。该区域在BldB家族中是保守的，表明二聚体形成可能是这些蛋白质的共同特征。
We have demonstrated that the bldB gene of Streptomyces coelicolor is required for the formation of aerial hyphae and the synthesis of antibiotics. We also found that BldB forms a higher-order complex (most likely a dimer) and that amino acid residues 20 to 78 are important for this interaction. This region is conserved in the BldB family, suggesting that dimer formation may be a common feature of these proteins.