Cytotoxic cembrenolides and steroids from the formosan soft coral Sarcophyton crassocaule
Cytotoxic cembrenolides and steroids from the formosan soft coral Sarcophyton crassocaule
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DOI：
10.1021/np0002381
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发表时间：
2000-12-01
影响因子：
5.1
通讯作者：
Dai, CF
中科院分区：
文献类型：
--
作者：
Duh, CY;Wang, SK;Dai, CF
从台湾珊瑚软珊瑚中分离得到三个新的细胞毒性灯盏花内酯二萜化合物，它们分别是：石蜡梅内酯(1)、景天花内酯(2)和13-乙酰氧基石蜡内酯(3)；已知的具有细胞毒性的灯盏花内酯(4)；(24S)-24-甲基胆烷-3-β，5-α，6-β-三醇(5)和24-Zeta-甲基胆烷-3-β，5-α，6-β，25-四醇-25-单乙酸酯(6)。通过一维和二维光谱分析确定了化合物1-6的结构。
Three new cytotoxic cembrenolide diterpenes, sarcocrassolide (1), crassolide (2), and 13-acetoxysarcocrassolide (3); a known cytotoxic cembrenolide, denticulatolide (4); and two cytotoxic steroids, (24S)-24-methylcholestane-3 beta ,5 alpha ,6 beta -triol (5) and 24 zeta -methylcholestane-3 beta ,5 alpha ,6 beta ,25-tetraol-25-monoacetate (6), have been isolated from the Formosan soft coral Sarcophyton crassocaule. The structures of compounds 1-6 were determined by 1D and 2D spectral analysis.