Alcohol drinking and renal cell carcinoma in Canadian men and women
Alcohol drinking and renal cell carcinoma in Canadian men and women
复制标题
DOI：
10.1016/j.cdp.2008.02.001
复制
发表时间：
2008-01-01
影响因子：
--
通讯作者：
Mery, Les
中科院分区：
文献类型：
--
作者：
Hu, Jinfu;Chen, Yue;Mery, Les
背景资料：流行病学研究报告称，适度饮酒与肾细胞癌（RCC）的风险呈负相关，但性别特异性结果不一致。本研究探讨了男性和女性酒精摄入量与RCC风险之间的关系。研究方法：邮寄问卷完成了1138个新诊断的，组织学确诊的RCC病例和5039人口控制1994年至1997年在加拿大8个省。食物频率问卷提供了数据收集前2年的饮食习惯和饮酒量数据。其他信息包括社会经济地位、生活习惯、饮酒和饮食。优势比（OR）和95%置信区间（CI）通过非条件logistic回归得出。结果如下：在男性和女性中，总酒精摄入量与RCC呈负相关;对于男性和女性，最高摄入量组（男性>= 22.3 g/天，女性>= 7.9 g/天）与不饮酒者相比的OR为0.7（95% CI，0.5-0.9）。对绝经状态的分析得出，最高饮酒组与非饮酒组的OR值分别为1.2（95%CI，0.7-2.1）和0.6（95%CI，0.4-0.9）。吸烟和肥胖不是重要的影响因素。结论：适度饮酒可能与男性和女性（主要是绝经后女性）肾细胞癌风险降低有关。(C)2008年国际预防肿瘤学会。由爱思唯尔有限公司出版。保留所有权利。
Background: Epidemiologic studies have reported that moderate alcohol consumption is inversely associated with the risk of renal cell carcinoma (RCC), but sex-specific results are inconsistent. The present study examines the association between alcohol intake and the risk of RCC among men and women. Methods: Mailed questionnaires were completed by 1138 newly diagnosed, histologically confirmed RCC cases and 5039 population controls between 1994 and 1997 in eight Canadian provinces. A food frequency questionnaire provided data on eating habits and alcohol consumption 2 years before data collection. Other information included socio-economic status, lifestyle habits, alcohol use, and diet. Odds ratios (ORs) and 95% confidence intervals (CIs) were derived through unconditional logistic regression. Results: Total alcohol intake was inversely associated with RCC in men and in women; the OR for the highest intake group (>= 22.3 g/day among men and >= 7.9 g/day among women) versus the non-drinkers was 0.7 (95% CI, 0.5-0.9) for both sexes. Analysis of menopausal status produced ORs for the highest intake group versus the non-drinkers of 1.2 (95% CI, 0.7-2.1) an long premenopausal women and 0.6 (95 % CI, 0.4-0.9) among postmenopausal women. Smoking and obesity were not important effect modifiers. Conclusion: Moderate alcohol consumption may be associated with a decreased risk of RCC in men and in women (mainly postmenopausal women). (C) 2008 International Society for Preventive Oncology. Published by Elsevier Ltd. All rights reserved.