Non-regulatory CD8+CD45RO+CD25+ T-lymphocytes may compensate for the loss of antigen-inexperienced CD8+CD45RA+ T-cells in old
Non-regulatory CD8+CD45RO+CD25+ T-lymphocytes may compensate for the loss of antigen-inexperienced CD8+CD45RA+ T-cells in old
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DOI：
10.1515/bc.2008.052
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发表时间：
2008-05-01
影响因子：
3.7
通讯作者：
Grubeck-Loebenstein, Beatrix
中科院分区：
文献类型：
--
作者：
Herndier-Brandstetter, Dietmar;Veel, Ellen;Grubeck-Loebenstein, Beatrix
与年龄有关的免疫系统功能下降是导致传染病发病率增加和老年人接种疫苗效果低下的原因。特别是，外周幼稚T细胞的数量在整个一生中都在下降，到了老年，它们表现出严重的功能缺陷。然而，我们最近发现了一种非调节性CD8(+)CD45RO(+)CD25(+)T细胞亚群，存在于健康老年人的亚群中，他们在接种流感疫苗后仍表现出完整的体液免疫反应。在这里，我们证明了CD8(+)CD45RO(+)CD25(+)T细胞与来自年轻人的幼稚CD8(+)CD45RA(+)CD28(+)T细胞具有相同的表型和功能特征，尽管他们表达CD45RO。CD8(+)CD45RO(+)CD25(+)T细胞也有较长的端粒，在抗原攻击下，它们在体外有效地扩增并分化为功能效应细胞。扩大的人口还保持了多样化的T细胞受体谱系。总之，老年人的CD8(+)CD45RO(+)CD25(+)T细胞弥补了功能性幼稚T细胞的丧失，因此可以作为老年免疫能力的标志。
The age-related decline in immune system functions is responsible for the increased prevalence of infectious diseases and the low efficacy of vaccination in elderly individuals. In particular, the number of peripheral naive T-cells declines throughout life and they exhibit severe functional defects at advanced age. However, we have recently identified a non-regulatory CD8(+)CD45RO(+) CD25(+) T-cell subset that occurs in a subgroup of healthy elderly individuals, who still exhibit an intact humoral immune response following influenza vaccination. Here, we demonstrate that CD8(+)CD45RO(+)CD25(+) T-cells share phenotypic and functional characteristics with naive CD8(+)CD45RA(+)CD28(+) T-cells from young individuals, despite their expression of CD45RO. CD8(+)CD45RO(+) CD25(+) T-cells also have long telomeres and upon antigenic challenge, they efficiently expand in vitro and differentiate into functional effector cells. The expanded population also maintains a diverse T-cell receptor repertoire. In conclusion, CD8(+)CD45RO(+)CD25(+) T-cells from elderly individuals compensate for the loss of functional naive T-cells and may therefore be used as a marker of immunological competence in old age.