Methyl‐CCNU, doxorubicin, and cis‐diaminedichloroplatinum II in the management of recurrent and metastatic squamous carcinoma of the cervix
Methyl‐CCNU, doxorubicin, and cis‐diaminedichloroplatinum II in the management of recurrent and metastatic squamous carcinoma of the cervix
复制标题
甲基-CCNU、阿霉素和顺式二胺二氯铂 II 治疗复发性和转移性宫颈鳞状细胞癌
作者：
B. J. Masterson;J. Carlson;T. Day;J. Allegra;T. Woodcock;R. Greenberg
23例复发性不可切除的宫颈癌或首次出现远处转移的患者在第1天接受甲基环己亚硝脲（175 mg/m2）和多柔比星（45 mg/m2）治疗，在第22天接受顺二胺二氯铂II（90 mg/m2）治疗，治疗周期为42天。22例患者患有鳞状细胞癌，1例患者患有腺鳞癌。有2例完全缓解（CR），5例部分缓解（PR）（肿瘤缩小>50%，持续时间>3个月），4例患者病情稳定（缩小<50%，持续时间>3个月），12例患者肿瘤进展。1例CR维持> 28个月，另1例CR维持>8个月。23例患者中有7例（30.4%）完全缓解（CR）或部分缓解（PR）。15例（20%）原发于盆腔的癌症患者中有3例缓解，而8例远处转移患者中有4例（50%）缓解。在最初的2个化疗周期中，12例患者发生骨髓抑制，定义为白细胞<3000/mm 3，粒细胞<1，000/mm 3或血小板<100，000/mm 3。未发生治疗相关死亡。
Twenty‐three patients with recurrent unresectable carcinoma of the cervix or distant metastasis at initial presentation were treated with methyl‐CCNU (175 mg/m2) and doxorubicin (45 mg/m2) on day 1 and Cis‐diaminedichloroplatinum II (90 mg/m2) on day 22 of a 42‐day treatment cycle. Twenty‐two patients had squamous carcinoma and 1 had adenosquamous carcinoma. There were two complete responses (CR), five partial responses (PR) (>50% tumor reduction, >3‐month duration), four patients with stable disease (<50% reduction, >3‐month duration), and 12 patients who had tumor progression. One CR has been maintained > 28 months, and the other >8 months. Total CR and PR was 7 of 23 (30.4%). Three responses occurred among 15 patients (20%) who had cancer primarily confined to the pelvis, while 4 of 8 patients (50%) with distant metastasis responded. During the initial 2 cycles of chemotherapy, 12 patients had myelosuppression, defined as a leukocytes <3000/mm3, granulocytes <1,000/mm3, or platelets <100,000/mm3. There were no treatment‐related deaths.
使用博莱霉素、长春新碱、丝裂霉素 C 和顺式二氯二氨铂（II）（BOMP）对晚期宫颈癌进行化疗。
DOI：
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发表时间：
1980
期刊：
Cancer treatment reports
影响因子：
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作者：
Vogl,SE;Moukhtar,M;Calanog,A;Greenwald,EH;Kaplan,BH
通讯作者：
Kaplan,BH