Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats
Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats
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DOI：
10.1037/0735-7044.112.5.1199
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发表时间：
1998-10-01
影响因子：
1.9
通讯作者：
Hoyer, S
中科院分区：
文献类型：
--
作者：
Lannert, H;Hoyer, S
散发性阿尔茨海默病患者的大脑葡萄糖和能量代谢发生严重异常，表明神经元胰岛素和胰岛素受体信号转导功能紊乱，是痴呆的原因之一。已知复方链脲佐菌素(STZ)可抑制胰岛素受体功能。本研究旨在探讨侧脑室注射链脲佐菌素(STZ)是否会抑制神经元的胰岛素受体功能，并导致行为和神经元能量代谢的改变。冰冻注射STZ的成年大鼠在学习、记忆和认知行为方面出现长期和进行性的缺陷，表现为在打孔板任务和被动回避范式中工作记忆和参考记忆的减少，以及永久性和持续性的脑能量缺乏。这种动物模型可能适用于与散发性阿尔茨海默病相关的研究。
Drastic abnormalities have been demonstrated to occur in cerebral glucose and energy metabolism in sporadic Alzheimer's disease, pointing to a primary disturbance in neuronal insulin and insulin receptor signal transduction and contributing to the causation of dementia. The compound streptozotocin (STZ) is known to inhibit insulin receptor function. The study was designed to investigate whether intracerebroventricularly (icv) applied STZ would inhibit neuronal insulin receptor function and would induce changes in both behavior and neuronal energy metabolism. Adult rats with icy-injected STZ developed long-term and progressive deficits in learning, memory, and cognitive behavior, indicated by decreases in working and reference memory in the holeboard task and the passive avoidance paradigm, along with a permanent and ongoing cerebral energy deficit. This animal model may be appropriate for investigations related to sporadic Alzheimer's dementia.