Clinical PET in Oncology.
Clinical PET in Oncology.
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DOI：
10.1016/s1095-0397(97)00004-6
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发表时间：
1998-12-01
期刊：
影响因子：
--
通讯作者：
Coleman, R Edward
中科院分区：
文献类型：
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作者：
Coleman, R Edward
临床PET的主要用途是肿瘤学，肿瘤PET使用FDG作为放射性药物。FDG成像显示与正常细胞相比，恶性细胞的代谢增加。FDG-PET在脑肿瘤中的初步临床应用，FDG的积聚程度与肿瘤的恶性程度有关。随后的研究证明了FDG-PET在检测和分期几种不同恶性肿瘤方面的准确性。全身显像对PET记录恶性肿瘤分布的能力产生了重大影响。FDG-PET显像在确定不确定的孤立性肺结节是否为恶性和肺癌分期方面非常准确。PET的成本效益已被证明适用于这些适应症。第三方付款人有政策支付PET扫描评估孤立性肺结节和肺癌分期。在其他恶性肿瘤中使用FDG-PET成像的初步数据支持其用于检测结直肠癌的肝转移，并将结直肠癌治疗后的纤维化与复发性肿瘤区分开来;对原发性乳腺癌的腋窝进行分期;对黑色素瘤和淋巴瘤进行分期;以及对头颈部癌症的复发进行分期和检测。关于FDG-PET在肌肉骨骼恶性肿瘤、卵巢癌、胰腺癌和甲状腺癌中的应用的初步报告令人鼓舞。
The major utilization of clinical PET is in oncology, and oncologic PET utilizes FDG as the radiopharmaceutical. FDG imaging demonstrates the increased metabolism by malignant cells compared to normal cells. The initial clinical application of FDG-PET was demonstrated in brain tumors, and the gradation of accumulation of FDG related to the degree of malignancy. Subsequent studies have documented the accuracy of FDG-PET in detecting and staging several different malignancies. Whole-body imaging has made a major impact on the ability of PET to document the distribution of malignancy.FDG-PET imaging is very accurate in determining if an indeterminate solitary pulmonary nodule is malignant and in staging lung cancer. The cost-effectiveness of PET has been demonstrated for these indications. Third-party payers have policies for paying for PET scans performed in the evaluation of solitary pulmonary nodules and in staging lung cancer. The preliminary data on the use of FDG-PET imaging in other malignancies supports its use in detecting liver metastases from colorectal cancer and differentiating fibrosis from recurrent tumor after therapy for colorectal cancer; staging the axilla in primary breast cancer; staging melanoma and lymphoma; and staging and detecting recurrence of head and neck cancer. The initial reports on the use of FDG-PET are encouraging in its use in musculoskeletal malignancy, ovarian cancer, pancreatic cancer, and thyroid cancer.