High b-value q-space analyzed diffusion-weighted MRI:: Application to multiple sclerosis
High b-value q-space analyzed diffusion-weighted MRI:: Application to multiple sclerosis
复制标题
DOI：
10.1002/mrm.10040
复制
发表时间：
2002-01-01
影响因子：
3.3
通讯作者：
Cohen, Y
中科院分区：
文献类型：
--
作者：
Assaf, Y;Ben-Bashat, D;Cohen, Y
多发性硬化症（MS）是一种中枢神经系统（CNS）的炎性疾病，其影响全世界近一百万人，导致运动和感觉功能的进行性下降和永久性残疾。高b值扩散加权磁共振成像（B高达14000 s/mm（2））从对照组和MS患者的大脑中获得。这些扩散MR图像，其中信号衰减不是单指数的，使用强调慢扩散成分的扩散特性的q-空间方法进行了分析。根据这一分析，构建了位移和概率图。计算的q空间分析的MR图像与传统的T-1，T-2（液体衰减反转恢复（FLAIR）），和扩散张量成像（DTI）图像相比，被发现是敏感的病理生理状态的白色物质。用于构建该q空间分析的MR图的指数提供了正常组织和通过FLAIR图像分类为MS斑块的组织之间的显著区分。更重要的是，在MS脑中由FLAIR MR图像分类为正常外观白色物质（NAWM）的组织（已知为异常）和相应的对照组织之间也观察到明显的差异。高b值扩散q空间分析的MR图像的潜在诊断能力进行了讨论，并提出了实验数据，解释了一旦违反短脉冲梯度近似使用q空间方法的后果。Magn Reson Med 47：115-126，2002年。(C)2002 Wiley-Liss，Inc.
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) which affects nearly one million people worldwide, leading to a progressive decline of motor and sensory functions, and permanent disability. High b-value diffusion-weighted MR images (b of up to 14000 s/mm(2)) were acquired from the brains of controls and MS patients. These diffusion MR images, in which signal decay is not monoexponential, were analyzed using the q-space approach that emphasizes the diffusion characteristics of the slow-diffusing component. From this analysis, displacement and probability maps were constructed. The computed q-space analyzed MR images that were compared with conventional T-1, T-2 (fluid attenuated inversion recovery (FLAIR)), and diffusion tensor imaging (DTI) images were found to be sensitive to the pathophysiological state of white matter. The indices used to construct this q-space analyzed MR maps, provided a pronounced differentiation between normal tissue and tissues classified as MS plaques by the FLAIR images. More importantly, a pronounced differentiation was also observed between tissues classified by the FLAIR MR images as normal-appearing white matter (NAWM) in the MS brains, which are known to be abnormal, and the respective control tissues. The potential diagnostic capacity of high b-value diffusion q-space analyzed MR images is discussed, and experimental data that explains the consequences of using the q-space approach once the short pulse gradient approximation is violated are presented. Magn Reson Med 47:115-126, 2002. (C) 2002 Wiley-Liss, Inc.