Chemical constituents from Nelumbo nucifera leaves and their anti-obesity effects
Chemical constituents from Nelumbo nucifera leaves and their anti-obesity effects
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DOI：
10.1016/j.bmcl.2013.04.013
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发表时间：
2013-06-15
影响因子：
2.7
通讯作者：
Lee, Mi Kyeong
中科院分区：
文献类型：
--
作者：
Ahn, Jong Hoon;Kim, Eun Sil;Lee, Mi Kyeong
Nelumbo nucifera Gaertn.（睡莲科），通常称为莲，广泛分布于整个东亚。长期以来，它一直被用作食品和药物。本文对N. nucifera叶中分离得到13个巨替加曼（megastigmanes）（1 - 13），包括一个新的巨替加曼（megastigmanes），莲心苷A（nelumnucifoside A）（1），和一个新的桉烷倍半萜，莲心苷B（14），8个生物碱（15-22），和11个黄酮（23-33）。通过1D、2D NMR和MS等波谱方法确定了它们的化学结构。用NOESY法和圆二色谱法分别测定了化合物的相对和绝对立体化学。化合物19和22显著抑制胰脂肪酶，而化合物15和16显示出对脂肪细胞分化的强烈抑制作用。因此，N.荷叶属植物通过抑制胰脂肪酶和脂肪细胞分化而具有作为抗肥胖剂的潜力。(C)2013爱思唯尔有限公司版权所有。
Nelumbo nucifera Gaertn. (Nymphaeaceae), commonly called lotus, is widely distributed throughout Eastern Asia. It has been used for food and medicine for a long time. A phytochemical investigation of N. nucifera leaves led to the isolation of 13 megastigmanes (1 -13), including a new megastigmane, nelumnucifoside A (1), and a new eudesmane sesquiterpene, nelumnucifoside B (14), eight alkaloids (15-22), and 11 flavonoids (23-33). Their chemical structures were determined based on spectroscopic methods including 1D, 2D NMR and MS spectrometry. The relative and absolute stereochemistry of the compounds was determined by NOESY and CD spectrometry, respectively. Compounds 19 and 22 significantly inhibited pancreatic lipase, whereas compounds 15 and 16 showed a strong inhibitory effect on adipocyte differentiation. Therefore, the leaves of N. nucifera have potential as an anti-obesity agent by inhibiting pancreatic lipase and adipocyte differentiation. (C) 2013 Elsevier Ltd. All rights reserved.