Prenatal stress elicits regionally selective changes in basal FGF-2 gene expression in adulthood and alters the adult response to acute or chronic stress
Prenatal stress elicits regionally selective changes in basal FGF-2 gene expression in adulthood and alters the adult response to acute or chronic stress
复制标题
DOI：
10.1016/j.nbd.2005.05.005
复制
发表时间：
2005-12-01
影响因子：
6.1
通讯作者：
Riva, MA
中科院分区：
文献类型：
--
作者：
Fumagalli, F;Bedogni, F;Riva, MA
怀孕期间暴露在压力下会影响大脑发育轨迹，导致永久性改变，可能导致随后的认知或神经精神疾病的易感性增加。在这篇手稿中，我们研究了成年雄性大鼠在基础条件下以及对急性或慢性应激的反应中，产前应激对碱性成纤维细胞生长因子（FGF-2）表达的影响，FGF-2是发育和可塑性的重要分子调节剂。不同脑区的基线 FGF-2 mRNA 水平受到妊娠应激的不同影响，前额皮质显着降低，内嗅皮质和纹状体显着增加。就其本身而言，产后压力同样会降低前额皮质中营养因子的表达，同时引起其他部位的刺激。妊娠应激改变了 FGF-2 响应成人应激的表达模式，完全逆转了前额叶皮层的模式（刺激性而非抑制性），减弱了内嗅皮层的反应并使纹状体的反应脱敏。这些效应表明，慢性产前应激对持续到成年期的 FGF-2 表达及其对后续应激源的反应产生独特的干扰。鉴于 FGF-2 在突触发育、维持和可塑性中的多方面作用，这些数据提供了详细的机制证据，说明产前应激如何引发对突触功能的终生影响。为了应对成年后的压力，特定大脑区域的 FGF-2 基因表达异常调节可能会损害细胞对挑战性情况的正常适应性反应。 (c) 2005 Elsevier Inc. 保留所有权利。
Exposure to stress during pregnancy influences the trajectory of brain development resulting in permanent alterations that may contribute to increased susceptibility to subsequent cognitive or neuropsychiatric disorders. In this manuscript, we examined the effects of prenatal stress on the expression of basic fibroblast growth factor (FGF-2), an important molecular regulator of development and plasticity, in adult male rats under basal conditions as well as in response to acute or chronic stress. Baseline FGF-2 mRNA levels were differentially influenced by gestational stress in a variety of brain regions, with significant decreases in prefrontal cortex and increases in entorhinal cortex and striatum. By itself, postnatal stress similarly decreased trophic factor expression in prefrontal cortex while evoking stimulation elsewhere. Gestational stress altered the pattern of FGF-2 expression in response to adult stress, completely reversing the pattern in the prefrontal cortex (stimulatory instead of inhibitory), blunting the response in the entorhinal cortex and desensitizing the response in the striatum. These effects point to a unique interference of chronic prenatal stress with both ongoing FGF-2 expression and its responses to subsequent stressors, lasting into adulthood.Given the multifaceted role of FGF-2 in synaptic development, maintenance and plasticity, these data provide detailed mechanistic evidence as to how prenatal stress elicits lifelong effects on synaptic function. The abnormal modulation of FGF-2 gene expression in specific brain regions in response to subsequent stress in adulthood may impair the normal adaptive responses ofthe cell to challenging situations. (c) 2005 Elsevier Inc. All rights reserved.