Au capped magnetic core/mesoporous silica shell nanoparticles for combined photothermo-/chemo-therapy and multimodal imaging
Au capped magnetic core/mesoporous silica shell nanoparticles for combined photothermo-/chemo-therapy and multimodal imaging
复制标题
用于组合光热/化疗和多模态成像的金盖帽磁芯/介孔二氧化硅壳纳米颗粒
DOI：
10.1016/j.biomaterials.2011.10.017
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发表时间：
2012-01-01
期刊：
影响因子：
14
通讯作者：
Shi, Jianlin
中科院分区：
文献类型：
--
作者：
Ma, Ming;Chen, Hangrong;Shi, Jianlin
基于两步化学自组装法，在磁性核/介孔二氧化硅壳纳米结构的外表面均匀包覆一层Au NR，制备了均匀的Au NR包覆的磁性核/介孔二氧化硅壳纳米椭球（Au NRs-MMSNEs）.这种多功能纳米复合材料将同步化疗、光热治疗、体内MR成像、红外热成像和光学成像集成到一个单一系统中。利用激光共聚焦显微镜和生物透射电子显微镜观察了多功能纳米椭球的细胞摄取和细胞内定位。重要的是，所制备的多功能纳米椭球体显示出高的阿霉素负载容量和pH值响应性释放，主要是由于DOX分子和介孔二氧化硅表面之间的静电相互作用。此外，基于DOX释放和Au NR的光热效应，在中等功率强度的NIR照射下发现了联合化疗和光热治疗的协同效应。(C)2011爱思唯尔有限公司保留所有权利。
Uniform Au NRs-capped magnetic core/mesoporous silica shell nanoellipsoids (Au NRs-MMSNEs) were prepared by coating a uniform layer of Au NRs on the outer surface of a magnetic core/mesoporous silica shell nanostructure, based on a two-step chemical self-assembly process. This multifunctional nanocomposite integrate simultaneous chemotherapy, photo-thermotherapy, in vivo MR-, infrared thermal and optical imaging into one single system. The obtained multifunctional nanoellipsoids showed very low cytotoxicity, and the cancer cell uptake and intracellular location of the nanoellipsoids were observed by confocal laser scanning microscopy and bio-TEM. Importantly, the prepared multifunctional nanoellipsoids showed high doxorubicin loading capacity and pH value-responsive release mainly due to the electrostatic interaction between DOX molecules and mesoporous silica surface. Besides, a synergistic effect of combined chemo- and photo-thermo therapy was found at moderate power intensity of NIR irradiation based on the DOX release and the photothermal effect of Au NRs. (C) 2011 Elsevier Ltd. All rights reserved.