The versatile functions of ATM kinase.
The versatile functions of ATM kinase.
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DOI：
10.4103/2319-4170.125655
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发表时间：
2014-01
影响因子：
5.5
通讯作者：
Xu B
中科院分区：
文献类型：
--
作者：
Boohaker RJ;Xu B
共济失调-毛细血管扩张突变激酶（ATM）是一种在维持基因组稳定性中起重要作用的激酶，其突变导致常染色体隐性遗传病共济失调-毛细血管扩张症。广泛的研究表明，激活的ATM信号到大量的蛋白质，以促进细胞周期检查点，DNA修复，以及在DNA双链断裂的情况下生理反应的许多其他方面。ATM还发挥功能作用，超出了良好的特征DNA损伤反应（DDR）。在这篇综述文章中，我们讨论了ATM在DDR中的分子机制，有丝分裂纺锤体检查点，以及ATM信号在癌症侵袭和转移中的过度活跃。
Ataxia-telangiectasia mutated (ATM) kinase, the mutation of which causes the autosomal recessive disease ataxia-telangiectasia, plays an essential role in the maintenance of genome stability. Extensive studies have revealed that activated ATM signals to a massive list of proteins to facilitate cell cycle checkpoints, DNA repair, and many other aspects of physiological responses in the event of DNA double-strand breaks. ATM also plays functional roles beyond the well-characterized DNA damage response (DDR). In this review article, we discuss the recent findings on the molecular mechanisms of ATM in DDR, the mitotic spindle checkpoint, as well as hyperactive ATM signaling in cancer invasion and metastasis.