Effect of eye removal on N-acetylaspartylglutamate immunoreactivity in retinal targets of the cat.
Effect of eye removal on N-acetylaspartylglutamate immunoreactivity in retinal targets of the cat.
复制标题
摘除眼睛对猫视网膜目标 N-乙酰天冬氨酰谷氨酸免疫反应性的影响。
DOI：
10.1016/0006-8993(91)90638-c
复制
发表时间：
1991
期刊：
影响因子：
2.9
通讯作者：
Irtenkauf,SM
中科院分区：
文献类型：
--
作者：
Tieman,SB;Moffett,JR;Irtenkauf,SM
内源性脑二肽N-乙酰基谷氨酸（NAAG）已被证实存在于视网膜神经节细胞的胞体和视网膜靶细胞的嗜神经细胞中。在本文中，我们报告的NAAG免疫反应性的神经胶质细胞在视网膜的目标是依赖于一个完整的视通路。去除一只眼睛产生了显着减少染色的嗜神经细胞在对侧膝状体核（LGN）的A层和同侧LGN的A1层。去除对侧的上级丘浅层的染色也减少。这些结果表明，NAAG是存在于视网膜神经节细胞的终端，并与NAAG在视觉突触传递的作用是一致的。
The endogenous brain dipeptideN-acetylaspartylglutamate (NAAG) has previously been demonstrated in the somata of retinal ganglion cells and the neurophil of retinal targets. In this paper we report that the NAAG immunoreactivity of the neuropil in the retinal targets is dependent on an intact optic pathway. Removal of one eye produced a marked decrease in the staining of the neurophil in layer A of the contralateral geniculate nucleus (LGN) and layer A1 of the ipsilateral LGN. There was also decreased staining in the superficial layers of the superior colliculus contralateral to the removal. These results suggest that NAAG is present in the terminals of retinal ganglion cells and is consistent with a role for NAAG in visual synaptic transmission.