Ticking fast or ticking slow, through Shc must you go?
Ticking fast or ticking slow, through Shc must you go?
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滴答快还是滴答慢，你一定要经过Shc吗？
DOI：
10.1126/sageke.2004.32.pe32
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Friedman,JeffreyS
中科院分区：
文献类型：
--
作者：
Martin,FlorentM;Friedman,JeffreyS
Circumstantial evidence places the p66 isoform of the adapter protein Shc in a position to mediate the accelerated aging phenotype displayed by mice expressing shortened forms of the tumor suppressor protein p53. We present a model in which p66shcmay be responsible for integrating signals from the p53 pathway with signals from the insulin-like growth factor-1/Daf pathway in mammals. A full understanding of how interactions between p53 and p66shcaffect longevity will require the production of animals with mutations in the genes encoding both proteins.
