Chemotherapy-induced Alteration of SDF-1/CXCR4 Expression in Bone Marrow-derived Mesenchymal Stem Cells From Adolescents and Young Adults With Acute Lymphoblastic Leukemia
Chemotherapy-induced Alteration of SDF-1/CXCR4 Expression in Bone Marrow-derived Mesenchymal Stem Cells From Adolescents and Young Adults With Acute Lymphoblastic Leukemia
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DOI：
10.1097/mph.0000000000000220
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发表时间：
2014-11-01
影响因子：
1.2
通讯作者：
Xia, Ruixiang
中科院分区：
文献类型：
--
作者：
Ge, Jian;Hu, Yan;Xia, Ruixiang
骨髓基质中的骨髓间充质干细胞（BMMSC）为造血提供了支架。趋化因子基质细胞衍生因子 1 (SDF-1) 及其受体 CXCR4 已被证明会影响造血干细胞的植入。然而，人们对 SDF-1/CXCR4 在调节人类 BM-MSC 中的功能知之甚少。作为解决这个问题的第一步，我们评估了一群患有急性淋巴细胞白血病 (ALL) 的青少年和年轻人的 BM-MSC 中 SDF1/CXCR4 的表达。我们发现 ALL 的 MSC 中 CXCR4 水平降低，SDF-1 水平升高。此外，ALL 的 MSC 中的细胞迁移似乎受到损害。这些变化通过化疗得以逆转。总而言之，SDF-1/CXCR4 表达的改变有可能被开发为监测化疗有效性的生物标志物。
Bone marrow-derived mesenchymal stem cells (BMMSCs) in the marrow stroma provide a scaffold for hematopoiesis. Chemokine stromal cell-derived factor-1 (SDF-1) and its receptor CXCR4 have been shown to affect the engraftment of hematopoietic stem cells. However, little is known about SDF-1/CXCR4's functions in regulating BM-MSCs in humans. As an initial step toward this issue, we have evaluated expression of SDF1/CXCR4 in the BM-MSCs from a cohort of adolescents and young adults with acute lymphoblastic leukemia (ALL). We found a decrease of the CXCR4 level and an increase of the SDF-1 level in these MSCs of ALL. Moreover, cell migration appeared to be impaired in the MSCs of ALL. These changes were reversed by chemotherapy. Taken together, alteration of SDF-1/CXCR4 expression could be potentially developed as biomarkers for monitoring the effectiveness of chemotherapy.