ISOLATION OF AN INFLUENZA-A VIRUS OF UNUSUAL SUBTYPE (H1N7) FROM PIGS IN ENGLAND, AND THE SUBSEQUENT EXPERIMENTAL TRANSMISSION FROM PIG TO PIG
ISOLATION OF AN INFLUENZA-A VIRUS OF UNUSUAL SUBTYPE (H1N7) FROM PIGS IN ENGLAND, AND THE SUBSEQUENT EXPERIMENTAL TRANSMISSION FROM PIG TO PIG
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DOI：
10.1016/0378-1135(94)90093-0
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发表时间：
1994-03-01
影响因子：
3.3
通讯作者：
MANVELL, RJ
中科院分区：
文献类型：
--
作者：
BROWN, IH;ALEXANDER, DJ;MANVELL, RJ
从一个农场的两头猪采集的鼻拭子中分离到一种新型H1 N7流感病毒（A/swine/Eng/191973/92），该农场最近因感染H1N1病毒（A/swine/Eng/195852/92）而出现临床疾病。在抗原性上，H1 N7病毒的血凝素（HA）与A/USSR/90/77的HA最接近，而神经氨酸酶（NA）似乎与A/马/布拉格/1/56（H7 N7）的NA最接近。实验感染A/swine/Eng/191973/92的猪出现轻度临床体征，在感染后长达9天将病毒排泄到鼻道中，尸检时表现正常，将病毒传播给哨兵猪，但8头猪中有7头未能血清转化。这些发现表明，H1 N7病毒对猪的致病性较低，导致病毒增殖有限，不足以刺激可检测的初级体液免疫应答。
A novel H1N7 influenza virus (A/swine/Eng/191973/92) was isolated from nasal swabs collected from two pigs on a farm where there had been recent clinical disease due to infection with an H1N1 virus (A/swine/Eng/195852/92). Antigenically, the haemagglutinin (HA) of the H1N7 virus was related most closely to the HA of A/USSR/90/77, whilst the neuraminidase (NA) appeared to be related most closely to the NA of A/equine/Prague/1/56 (H7N7). Pigs infected experimentally with A/swine/Eng/191973/92 developed mild clinical signs, excreted virus into the nasal passages for up to nine days after infection, appeared normal at necropsy, transmitted the virus to sentinel pigs, but seven out of eight pigs failed to seroconvert. These findings suggest that the H1N7 virus has a low pathogenicity for pigs, resulting in limited virus multiplication which is insufficient to stimulate a detectable primary humoral immune response.