Coffee and metabolic phenotypes: A cross-sectional analysis of the Japan multi-institutional collaborative cohort (J-MICC) study
Coffee and metabolic phenotypes: A cross-sectional analysis of the Japan multi-institutional collaborative cohort (J-MICC) study
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DOI：
10.1016/j.numecd.2022.12.019
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发表时间：
2023-02-15
影响因子：
3.9
通讯作者：
Matsuo，Keitaro
中科院分区：
文献类型：
--
作者：
Watanabe，Takeshi;Arisawa，Kokichi;Matsuo，Keitaro
背景与目的到目前为止，咖啡摄入量与代谢表型之间的关系几乎还没有被研究过，而且仍然存在争议。因此，这项横断面研究的目的是检验日本人群中咖啡消费与代谢表型之间的关系。方法和结果我们分析了日本多机构合作队列研究基线调查中26,363名年龄在35-69岁的受试者的数据。咖啡消费量通过问卷调查进行评估。代谢综合征(METS)是根据2009年联合中期声明标准定义的，使用体重指数(BMI)而不是腰围。按有无肥胖(正常体重：体重指数和体重指数；肥胖：体重指数≥25公斤/平方米)分层的受试者按蛋氨酸成分的数量进行分类(代谢健康：无成分；在调整了性别、年龄和其他潜在混杂因素的多元Logistic回归分析中，在正常体重(OR0.83，95%CI0.76-0.90)和肥胖者(OR0.83，95%CI0.69-0.99)中，高咖啡摄入量(≥3杯/天)与代谢不健康表型的发生率较低相关。过滤/速溶咖啡的摄入量与代谢不良表型的患病率呈负相关，而罐装/瓶装/包装咖啡的摄入量与代谢不健康表型的患病率呈负相关。结论在正常体重和肥胖的日本成年人中，大量饮用咖啡，尤其是滤/速溶咖啡，与代谢不健康表型的患病率呈负相关。
Background and aimsTo date, the relationship between coffee consumption and metabolic phenotypes has hardly been investigated and remains controversial. Therefore, the aim of this cross-sectional study is to examine the associations between coffee consumption and metabolic phenotypes in a Japanese population.Methods and resultsWe analyzed the data of 26,363 subjects (aged 35–69 years) in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. Coffee consumption was assessed using a questionnaire. Metabolic Syndrome (MetS) was defined according to the Joint Interim Statement Criteria of 2009, using body mass index (BMI) instead of waist circumference. Subjects stratified by the presence or absence of obesity (normal weight: BMI <25 kg/m2; obesity: BMI ≥25 kg/m2) were classified by the number of MetS components (metabolically healthy: no components; metabolically unhealthy: one or more components) other than BMI.In multiple logistic regression analyses adjusted for sex, age, and other potential confounders, high coffee consumption (≥3 cups/day) was associated with a lower prevalence of MetS and metabolically unhealthy phenotypes both in normal weight (OR 0.83, 95% CI 0.76–0.90) and obese subjects (OR 0.83, 95% CI 0.69–0.99). Filtered/instant coffee consumption was inversely associated with the prevalence of MetS and metabolically unhealthy phenotypes, whereas canned/bottled/packed coffee consumption was not.ConclusionThe present results suggest that high coffee consumption, particularly filtered/instant coffee, is inversely associated with the prevalence of metabolically unhealthy phenotypes in both normal weight and obese Japanese adults.