The role of macrophages and dendritic cells in the initiation of inflammation in IBD.
The role of macrophages and dendritic cells in the initiation of inflammation in IBD.
复制标题
巨噬细胞和树突状细胞在 IBD 炎症引发中的作用。
DOI：
10.1097/mib.0b013e3182a69dca
复制
发表时间：
2014-01
影响因子：
4.9
通讯作者：
Plevy SE
中科院分区：
文献类型：
--
作者：
Steinbach EC;Plevy SE
在健康的胃肠道中，体内平衡是一个积极的过程，需要宿主对肠道内容物的反应保持谨慎的平衡。肠道巨噬细胞和树突状细胞是一组独特的组织免疫细胞，它们理想地位于宿主和肠道腔环境的界面，以适当地响应微生物和摄入的刺激。然而，巨噬细胞和树突状细胞功能的内在缺陷有助于炎症性肠病（IBD）的发病机制，最近的全基因组关联研究强调了这一点。胃肠道巨噬细胞和树突状细胞通过对肠道微生物刺激的不适当反应，宿主组织中微生物的低效清除，以及从适当的促炎反应到促进缓解的抗炎反应的过渡受损，参与IBD的发展。通过了解肠道巨噬细胞和树突状细胞如何引发慢性炎症，将阐明新的基于发病机制的治疗人类IBD的治疗策略。
In the healthy gastrointestinal tract, homeostasis is an active process that requires a careful balance of host responses to the enteric luminal contents. Intestinal macrophages and dendritic cells comprise a unique group of tissue immune cells that are ideally situated at the interface of the host and the enteric luminal environment to appropriately respond to microbes and ingested stimuli. However, intrinsic defects in macrophage and dendritic cell function contribute to the pathogenesis of inflammatory bowel diseases (IBD), as highlighted by recent genome-wide association studies. Gastrointestinal macrophages and dendritic cells participate in IBD development through inappropriate responses to enteric microbial stimuli, inefficient clearance of microbes from host tissues, and impaired transition from appropriate pro-inflammatory responses to anti-inflammatory responses that promote resolution. By understanding how intestinal macrophages and dendritic cells initiate chronic inflammation, new pathogenesis-based therapeutic strategies to treat human IBD will be elucidated.