Relationship between psychiatric status and frontal-subcortical systems in HIV-infected individuals
Relationship between psychiatric status and frontal-subcortical systems in HIV-infected individuals
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DOI：
10.1017/s135561770707066x
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发表时间：
2007-05-01
影响因子：
2.6
通讯作者：
Hinkin, Charles H.
中科院分区：
文献类型：
--
作者：
Cole, Michael A.;Castellon, Steven A.;Hinkin, Charles H.
人类免疫缺陷病毒（HIV）感染的成年人经常表现出神经认知和精神功能障碍。据推测，冷漠和易怒，而不是焦虑和抑郁，与艾滋病毒对额叶皮层下系统的影响有关。通过确定这些精神病学特征与神经认知功能相关的程度来评估这一假设，神经认知功能依赖于额叶皮层下回路，因此被认为对HIV的中枢神经系统影响敏感。评定量表评估易怒，冷漠，抑郁，焦虑和双重任务的范例管理189艾滋病毒血清阳性（HIV+）和53艾滋病毒血清阴性的参与者。在HIV+参与者中观察到双重任务表现的缺陷以及更大的焦虑、抑郁、冷漠和易怒。同时进行的多元回归和共同性分析显示，只有冷漠和易怒与艾滋病毒+参与者的双重任务性能。因此，这些发现表明，冷漠和易怒，而不是抑郁和焦虑，可能与艾滋病毒对额叶皮层下回路的影响有关。
Human immunodeficiency virus (HIV)-infected adults frequently evidence both neurocognitive and psychiatric dysfunction. It was hypothesized that apathy and irritability, but not anxiety and depression, are related to HIV effects on frontal-subcortical systems. This hypothesis was evaluated by determining the degree to which these psychiatric features are associated with neurocognitive functioning that is dependent upon frontal-subcortical circuitry and, therefore, thought to be sensitive to the central nervous system effects of HIV. Rating scales assessing irritability, apathy, depression, and anxiety and a dual-task paradigm were administered to 189 HIV-seropositive (HIV+) and 53 HIV-seronegative participants. Deficits in dual-task performance and greater anxiety, depression, apathy, and irritability were observed in HIV+ participants. Simultaneous multivariate regression and communality analyses revealed that only apathy and irritability were associated with dual-task performance in HIV+ participants. Thus, these findings suggest that apathy and irritability, but not depression and anxiety, are likely associated with the effects of HIV on frontal-subcortical circuitry.