Palladium-catalyzed asymmetric allylic alkylation with an indenide
Palladium-catalyzed asymmetric allylic alkylation with an indenide
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DOI：
10.1016/j.tetasy.2003.11.028
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发表时间：
2004-02-09
影响因子：
--
通讯作者：
Kawatsura, M
中科院分区：
文献类型：
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作者：
Hayashi, T;Suzuka, T;Kawatsura, M
在钯催化剂的催化下，1，3-二苯基-2-丙烯基乙酸乙酯在钯催化剂的催化下，通过不对称烯丙基取代1，3-二苯基-2-丙烯基乙酸乙酯，实现了对映体的不对称合成。烯丙基取代吲哚的立体化学为净保留。(C)2003爱思唯尔有限公司。保留所有权利。
Catalytic asymmetric synthesis of a chiral indene (97% ee) was realized by asymmetric allylic substitution of 1,3-diphenyl-2-propenyl acetate with an indenide generated from indene and cesium carbonate in the presence of a palladium catalyst coordinated with (S)-Ph-phox. The stereochemistry of the allylic substitution with the indenide was demonstrated to be net retention. (C) 2003 Elsevier Ltd. All rights reserved.