Effects of agar (kanten) diet on obese patients with impaired glucose tolerance and type 2 diabetes
Effects of agar (kanten) diet on obese patients with impaired glucose tolerance and type 2 diabetes
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DOI：
10.1111/j.1463-1326.2004.00370.x
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发表时间：
2005-01-01
影响因子：
5.8
通讯作者：
Tochikubo, O
中科院分区：
文献类型：
--
作者：
Maeda, H;Yamamoto, R;Tochikubo, O
目的：本研究的目的是评估琼脂饮食与传统饮食（传统日本食品）相结合的肥胖患者的糖耐量受损和2型diabetes.Methods：经过4周的磨合期，他们的习惯饮食，76例患者被随机分配到有传统饮食或传统饮食与琼脂的疗效。这两组人都吃了12周的这些食物。体重，体重指数（BMI），血糖控制，血压，胰岛素抵抗，全身脂肪，脂肪分布和血脂进行了评估之前和之后的实验periods.Results：在两组，12周后，平均体重，BMI，空腹血糖水平，稳态模型评估胰岛素抵抗，收缩压和舒张压从基线值显着下降。琼脂饮食组的HbA 1 c、内脏脂肪面积、皮下脂肪面积、总体脂、口服葡萄糖耐量试验后胰岛素曲线下面积和总胆固醇显著降低。12周后，体重的平均变化（-2.8+/-2.7 kg vs. -1.3+/-2.3 kg，p=0.008），BMI值（-1.1+/-1.1 kg/m2 vs. -0.5+/-0.9 kg/m2，p=0.009）和总胆固醇（-7.6+/-27.5 mg/dl vs. +2.4+/-23.4 mg/dl，p=0.036），琼脂饮食组显著高于常规饮食组。琼脂饮食导致体重明显减轻，这是由于维持了减少的卡路里摄入量和代谢参数的改善。
Aim: The aim of this study was to evaluate the efficacy of agar diet in combination with a conventional diet (traditional Japanese food) for obese patients with impaired glucose tolerance and type 2 diabetes.Methods: After a 4-week run-in period on their habitual diets, 76 patients were randomly assigned to have conventional diet or conventional diet with agar. Both groups were on these diets for 12 weeks. Body weight, body mass index (BMI), glycaemic control, blood pressure, insulin resistance, total body fat, fat distribution and lipids were assessed before and after the experimental period.Results: In both groups, after 12 weeks, mean body weight, BMI, fasting glucose levels, homeostasis model assessment-insulin resistance, and systolic and diastolic blood pressures had decreased significantly from their baseline values. HbA(1)c, visceral fat area, subcutaneous fat area, total body fat, insulin area under the curve after oral glucose tolerance test and total cholesterol decreased significantly in the agar-diet group. After 12 weeks, mean changes of body weight (-2.8+/-2.7 kg vs. -1.3+/-2.3 kg, p=0.008), BMI values (-1.1+/-1.1 kg/m(2) vs. -0.5+/-0.9 kg/m(2), p=0.009) and total cholesterol (-7.6+/-27.5 mg/dl vs. +2.4+/-23.4 mg/dl, p=0.036) were significantly greater in the agar-diet group than in the conventional diet group.Conclusions: The agar diet resulted in marked weight loss due to the maintenance of reduced calorie intake and to an improvement in metabolic parameters.