Adherence to HAART in French HIV-infected injecting drug users: the contribution of buprenorphine drug maintenance treatment
Adherence to HAART in French HIV-infected injecting drug users: the contribution of buprenorphine drug maintenance treatment
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DOI：
10.1097/00002030-200001280-00010
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发表时间：
2000-01-28
期刊：
影响因子：
3.8
通讯作者：
Moreau, J
中科院分区：
文献类型：
--
作者：
Moatti, JP;Carrieri, MP;Moreau, J
目的：评估法国一组通过注射吸毒（IDU）感染HIV的患者对高效抗逆转录病毒治疗（HAART）的依从性，以及自1996年以来广泛引入的丁丙诺啡门诊药物维持治疗（DMT）对依从性的影响。设计：在MAN-IF2000队列研究中，开始HAART治疗后首次就诊时的依从性评估。方法：采用面对面问卷和自填问卷。单因素和逻辑回归调整了优势比（OR）来比较非依从性患者和依从性患者的特征。结果：在164例患者中，34.8%的患者在前一周服用了少于80%的HAART处方剂量。开始HAART治疗后病毒载量滴度的下降在非依从性患者中明显较低。经逻辑回归调整后，不依从性与年龄更小、饮酒、前6个月负面生活事件的频率和积极使用药物有关。然而，IDU在丁丙诺啡DMT中的依从性（78.1%）高于未IDU的依从性（65.5%），尽管这种差异没有达到统计学意义。结论：丁丙诺啡DMT处方可增加艾滋病毒感染阿片类药物依赖患者对HAART的依从性。应考虑通过社会心理干预减少压力生活事件的负面影响，即使对那些已经停止使用药物的人也是如此。(C) 2000 Lippincott Williams & Wilkins。
Objectives: To assess adherence to highly active antiretroviral therapies (HAART) in a cohort of French patients infected by HIV through injection drug use (IDU), and the impact on adherence of buprenorphine ambulatory drug maintenance treatment (DMT) which has been widely introduced since 1996.Design: Adherence assessment at first visit after initiation of HAART in the MAN-IF2000 cohort study.Methods: Patient's face-to-face and self-administered questionnaires. Univariate and logistic regression adjusted odds ratios (OR) to compare characteristics of nonadherent versus adherent patients.Results: Of the 164 patients, 34.8% took less than 80% of the prescribed HAART doses during the previous week. Decrease in viral load titres after initiation of HAART was significantly lower among non-adherent patients. After adjustment by logistic regression, non-adherence was associated with younger age, alcohol consumption, frequency of negative life-events during the prior 6 months and active drug use. However, IDU in buprenorphine DMT reached higher levels of adherence (78.1%) than ex-IDU (65.5%), although this difference did not reach statistical significance.Conclusion: Prescription of buprenorphine DMT may increase adherence to HAART among HIV-infected opiate-dependent patients. Reducing the negative impact of stressful life-events through psychosocial interventions should be considered, even for those who have stopped using drugs. (C) 2000 Lippincott Williams & Wilkins.