Neuropeptide Y is a mediator of chronic vascular and metabolic maladaptations to stress and hypernutrition
Neuropeptide Y is a mediator of chronic vascular and metabolic maladaptations to stress and hypernutrition
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DOI：
10.1258/ebm.2010.009136
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发表时间：
2010-10-01
影响因子：
3.2
通讯作者：
Zukowska, Zofia
中科院分区：
文献类型：
--
作者：
Abe, Ken;Kuo, Lydia;Zukowska, Zofia
神经肽Y(NPY)是一种中枢神经递质和外周交感神经递质，在应激状态下对心血管、神经内分泌、免疫和代谢功能也具有重要的调节作用。着重于该肽在啮齿动物模型中的外周作用，我们总结了我们实验室最近的研究表明，应激诱导NPY的释放介导了动脉粥样硬化/再狭窄、肥胖和代谢样综合征的加速，特别是当与高脂肪、高糖饮食相结合时。在这篇综述中，我们提出了当慢性应激与先前存在的血管损伤和/或高营养状态相关时，NPY的作用、其受体和细胞底物增加心血管和代谢性疾病风险的机制。
Neuropeptide Y (NPY) is a central neuromodulator and peripheral sympathetic neurotransmitter that also has important regulatory roles in cardiovascular, neuroendocrine, immune and metabolic functions during stress. Focusing on the peripheral actions of the peptide in rodent models, we summarize recent studies from our laboratory demonstrating that stress-induced release of NPY mediates accelerated atherosclerosis/restenosis, obesity and metabolic-like syndrome, particularly when combined with a high fat, high sugar diet. In this review, we propose mechanisms of NPY's actions, its receptors and cellular substrates that increase the risk for cardiovascular and metabolic diseases when chronic stress is associated with pre-existing vascular injury and/or states of hypernutrition.