Protecting cognition from aging and Alzheimer's disease: a computerized cognitive training combined with reminiscence therapy
Protecting cognition from aging and Alzheimer's disease: a computerized cognitive training combined with reminiscence therapy
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DOI：
10.1002/gps.4328
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发表时间：
2016-04-01
影响因子：
4
通讯作者：
Caltagirone, Carlo
中科院分区：
文献类型：
--
作者：
Barban, Francesco;Annicchiarico, Roberta;Caltagirone, Carlo
本文的目的是评估基于过程的认知训练（pb-CT）结合回忆疗法（RT）在轻度阿尔茨海默病（mAD）和轻度认知障碍（MCI）患者和健康老年人（HE）subjects.MethodsThis多中心，随机，对照试验涉及348名参与者与mAD，MCI，和HE从四个欧洲国家。受试者被随机分配到交叉设计的两组：A组接受为期3个月的计算机化pb-CT记忆和执行功能检查，并结合RT和3个月的休息; B组则相反。主要结果是训练对记忆和执行功能表现的影响。次要的结果是功能能力的训练的影响，在mAD评估与工具的日常living. ResultsResultsWe活动发现一个显着的效果，在所有三个组的记忆训练延迟召回雷伊听觉言语学习测试和执行功能在他的语音流畅性测试。MCI和HE参与者在随访时保持了这些效果。MCI和mAD受试者在简易精神状态检查量表上也显示出显著的训练效果。与mAD的参与者表现出更稳定的工具的日常生活活动，在训练与休息periods.ConclusionsOur结果证实了积极的影响pb-CT和它的维护主要对记忆在HE和MCI参与者，似乎没有被增强RT。此外，我们的结果是非常有前途的mAD参与者。版权所有（c）2015约翰威利父子有限公司
ObjectiveThe aim of this paper was to assess the efficacy of process-based cognitive training (pb-CT) combined with reminiscence therapy (RT) in patients with mild Alzheimer's disease (mAD) and mild cognitive impairment (MCI) and in healthy elderly (HE) subjects.MethodsThis multicenter, randomized, controlled trial involved 348 participants with mAD, MCI, and HE from four European countries. Participants were randomly assigned to two arms of a crossover design: those in arm A underwent 3months of computerized pb-CT for memory and executive functions combined with RT and 3months of rest; those in arm B underwent the reverse. The primary outcome was the effect of the training on memory and executive functions performance. The secondary outcome was the effect of the training on functional abilities in mAD assessed with the instrumental activities of daily living.ResultsWe found a significant effect of the training for memory in all three groups on delayed recall of the Rey Auditory Verbal Learning Test and for executive functions in HE on the phonological fluency test. MCI and HE participants maintained these effects at follow-up. MCI and mAD participants also showed a significant effect of the training on the Mini-mental state examination scale. Participants with mAD showed more stable instrumental activities of daily living during the training versus the rest period.ConclusionsOur results corroborate the positive effect of pb-CT and its maintenance primarily on memory in HE and MCI participants that did not seem to be potentiated by RT. Moreover, our results are very promising for the mAD participants. Copyright (c) 2015 John Wiley & Sons, Ltd.