Development of αβ T Cells with Innate Functions.
Development of αβ T Cells with Innate Functions.
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具有先天功能的αβ T 细胞的发育。
DOI：
10.1007/978-981-16-8387-9_10
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发表时间：
2022
影响因子：
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通讯作者：
Alberola-Ila,José
中科院分区：
文献类型：
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作者：
Alberola-Ila,José
虽然我们大多认为αβ T细胞是适应性免疫系统的组成部分，但它们中的一些分化成其他谱系。这些谱系表达的TCRs多样性有限，在功能上弥补了先天免疫和适应性免疫之间的差距。它们往往驻留在组织中，在激活后非常迅速地产生有效的细胞因子反应，它们的发育和功能成熟受到微生物组的强烈影响。在这里，我们比较了自然杀伤T细胞（NKT）和粘膜相关不变T细胞（MAIT细胞）的发育途径及其与微生物组的相互作用，这两种细胞是研究得最好的“先天样”αβ T细胞群。
Although we mostly think of αβ T cells as components of the adaptive immune system, a number of them differentiate into alternative lineages. These lineages express TCRs with limited diversity, and functionally bridge the gap between innate and adaptive immunity. They tend to be tissue resident, and mount potent cytokine responses very rapidly after activation, and their development and functional maturation are strongly influenced by the microbiome. Here, we compare the development pathways and interactions with the microbiome of natural killer T (NKT) cells and mucosal-associated invariant T (MAIT cells), the two best studied “innate-like” αβ T cell populations.