Size, shape, structure, and direction of angiogenesis in laryngeal tumour development
Size, shape, structure, and direction of angiogenesis in laryngeal tumour development
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DOI：
10.1136/jcp.2002.004978
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发表时间：
2004-04-01
影响因子：
3.4
通讯作者：
Stenbäck, F
中科院分区：
文献类型：
--
作者：
Laitakari, J;Näyhä, V;Stenbäck, F
目的：血管生成和血管组织在喉肿瘤的发展和进展进行了检查，以确定生物学和临床relevant.Methods的特点：自动定量图像分析进行了1451因子VIII（FVIII）相关的血管方面的发生，结构，大小，形状和染色强度，除了血管方向。除了鳞状细胞癌外，在癌前状态和严重不典型增生中血管数量增加，在低分化癌中更大。良性肿瘤以规则的小血管为主，恶性肿瘤以不规则的大血管为主。血管分布与鳞状细胞癌的分化程度有关，在分化良好的肿瘤中发生周向血管生成，在中等分化的肿瘤中发生定向血管生成，在分化较差的肿瘤中发生异常血管生成。血管形态的改变随着恶性程度的增加而显著增加。比较个别血管的特征显示血管形状异常和FVIII染色的强度增加与vessel size.Conclusions：血管生成增加是喉肿瘤发展的早期事件，与血管结构，大小和形状相关的肿瘤生长模式和行为。
Aims: Angiogenesis and vessel organisation in laryngeal tumour development and progression were examined to determine characteristics of biological and clinical relevance.Methods: Automated quantitative image analysis was performed on 1451 factor VIII ( FVIII) associated blood vessels with regard to occurrence, structure, size, shape, and staining intensity, in addition to vessel direction.Results: Vessel numbers were increased in preneoplastic states and severe dysplasia, in addition to squamous cell carcinomas, being greater in poorly differentiated carcinomas. Small regular vessels predominated in benign conditions and large, irregular vessels in malignant neoplasms. Vessel distribution was related to degree of differentiation in squamous cell carcinomas, with circumferential angiogenesis occurring in well differentiated neoplasms, directional angiogenesis in moderately differentiated tumours, and aberrant angiogenesis in less well differentiated neoplasms. Alterations in vessel shape increased significantly with increasing degree of malignancy. Comparing the characteristics of individual vessels showed vessel shape abnormalities and the intensity of FVIII staining to increase with vessel size.Conclusions: Increased angiogenesis was an early event in laryngeal tumour development, with vessel structure, size, and shape related to the tumour growth pattern and behaviour.