Fertility-sparing surgery in young women with invasive epithelial ovarian cancer
Fertility-sparing surgery in young women with invasive epithelial ovarian cancer
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DOI：
10.1016/j.ejso.2010.01.005
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发表时间：
2010-04-01
期刊：
影响因子：
3.8
通讯作者：
Kikkawa, F.
中科院分区：
文献类型：
--
作者：
Kajiyama, H.;Shibata, K.;Kikkawa, F.
目的：本研究的目的是阐明IA期或更晚期的上皮性卵巢癌（EOC）患者接受生育保留手术（FSS）治疗的临床结局。方法：在对多个机构的病历进行中心病理审查和检索后，本研究回顾性评估了60例接受FSS治疗的I期EOC患者。中位年龄为30岁（范围：12 - 40岁）。中位随访时间为54.7个月（范围：4.8 - 243.8个月）。IA期30例，TB期1例，IC期29例。52名患者存活且无复发，8名患者经历复发{1A，2; IB，1; IC（表面受累），1;和IC（阳性细胞学），4}。然而，所有IC期（包膜破裂）患者（n = 17）均存活，无复发。总体而言，IA期和IC期组的总生存率无显著差异（P = 0.256）。此外，IC期（包膜破裂）和IA期患者的DFS和OS无显著差异。相比之下，lC期（表面受累/细胞学阳性）患者的DFS和OS低于IA期患者（分别为OS; P = 0.030和DFS; P = 0.005）。13妊娠观察9 patients.Conclusions：FSS可被认为是一种治疗选择，在妇女与I期EOC，即使在那些与IC阶段（囊破裂）或更希望承担孩子。(c)2010爱思唯尔有限公司版权所有。
Objectives: The purpose of this study was to clarify the clinical outcome of patients with stage IA or more advanced epithelial ovarian cancer (EOC) treated with fertility-sparing surgery (FSS).Methods: After a central pathological review and search of the medical records from multiple institutions, a total of 60 stage I EOC patients treated with FSS were retrospectively evaluated in the current study.Results: The median age was 30 years (range: 12-40 years). The median follow-up time was 54.7 months (range: 4.8-243.8 months). The stage was IA in 30, TB in one, and IC in 29 patients. Fifty-two patients were alive without relapse and 8 patient experienced recurrences {1A, 2; IB, 1; IC(surface involvement), 1; and IC(positive cytology), 4}. However, all patients with stage IC(capsule rupture) (n = 17) were alive without recurrence. Collectively, there was no significant difference in the overall survival between the stage IA and IC groups (P = 0.256). Moreover, there was no significant difference in DFS and OS between patients with stage IC(capsule rupture) and those with stage IA. In contrast, DFS and OS of the patients with stage lC(surface involvement/positive cytology) were poorer than those of patients with stage IA (OS; P = 0.030, and DFS; P = 0.005, respectively). Thirteen pregnancies were observed in 9 patients.Conclusions: FSS may be considered a treatment option in women with stage I EOC, even in those with stage IC(capsule rupture) or more wishing to bear children. (c) 2010 Elsevier Ltd. All rights reserved.