DISTRIBUTION AND METABOLISM OF ACETALDEHYDE IN RATS DURING ETHANOL OXIDATION .1. DISTRIBUTION OF ACETALDEHYDE IN LIVER, BRAIN, BLOOD AND BREATH
DISTRIBUTION AND METABOLISM OF ACETALDEHYDE IN RATS DURING ETHANOL OXIDATION .1. DISTRIBUTION OF ACETALDEHYDE IN LIVER, BRAIN, BLOOD AND BREATH
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DOI：
10.1016/0006-2952(77)90310-0
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发表时间：
1977-01-01
影响因子：
5.8
通讯作者：
SIPPEL, HW
中科院分区：
文献类型：
--
作者：
ERIKSSON, CJP;SIPPEL, HW
对乙醇代谢过程中乙醛（AcH）的分布进行了体内研究。对96只雄性和雌性Sprague-Dawley大鼠口服不同剂量的乙醇，并在不同时间测量肝脏、血液、大脑和呼吸中的乙酰胆碱。肝脏是乙醇衍生乙酰胆碱氧化的主要部位。在这个器官中形成的总乙酰胆碱只有一小部分逃逸到身体的其他部位，但这一数量随着肝脏乙醇浓度的增加而增加。在相同乙醇浓度下，雄性大鼠肝脏乙酰胆碱水平高于雌性大鼠。肝外动脉血、脑血和尾外周血中乙酰胆碱含量与相应的肝内乙酰胆碱含量有良好的相关性。大部分肝脏乙酰胆碱输出被排除在肝外，从最初离开肝脏的乙酰胆碱水平急剧改变。性别差异也出现在肝外血AcH水平上，雌性大鼠表现出较高的AcH水平，这是由于其肝外乙酰胆碱清除效率较低。外周尾血AcH与加入肝血AcH前静脉血AcH水平相近。不管肝脏和血液中的乙酰胆碱含量如何，大脑中没有发现乙酰胆碱。不到5%的肝乙酰胆碱输出被呼出。戊巴比妥麻醉可明显抑制乙酰胆碱的呼出量。呼吸中的乙酰胆碱并不能像血液中的乙酰胆碱那样反映肝脏中的乙酰胆碱。
An in vivo investigation was made of the distribution of acetaldehyde (AcH) during ethanol metabolism. Different doses of ethanol were administered orally to male and female Sprague-Dawley rats (n = 96) and AcH measured at various times in the liver, blood, brain and breath. The liver was the primary site for the oxidation of the ethanol-derived AcH. Only a small amount of the total AcH formed in this organ escaped into the rest of the body, but this amount increased with increased hepatic ethanol concentration. The hepatic AcH level was higher in male rats than in females with the same hepatic ethanol concentration. The extrahepatic AcH levels in arterial cerebral and in peripheral tail blood correlated well with the corresponding hepatic AcH levels. The bulk of the hepatic AcH output was eliminated extrahepatically, drastically changing the AcH level from that initially leaving the liver. Sex differences also appeared in the extrahepatic blood AcH levels, with the female rats displaying higher AcH levels, as a result of their less efficient extrahepatic AcH elimination. The peripheral tail blood AcH was similar to the AcH level of the venous blood before the hepatic blood AcH is added to it. Regardless of the AcH levels in the liver and blood, no AcH was found in the brain. Less than 5% of the hepatic AcH output was exhaled. Pentobarbital anesthesia strongly depressed the amount of AcH exhaled. The AcH in the breath did not reflect the hepatic AcH as well as the blood AcH levels did.