COEXISTENT PULMONARY AND PORTAL-HYPERTENSION - MORPHOLOGICAL AND CLINICAL-FEATURES
COEXISTENT PULMONARY AND PORTAL-HYPERTENSION - MORPHOLOGICAL AND CLINICAL-FEATURES
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DOI：
10.1016/s0735-1097(87)80123-7
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发表时间：
1987-12-01
影响因子：
24
通讯作者：
EDWARDS, JE
中科院分区：
文献类型：
--
作者：
EDWARDS, BS;WEIR, EK;EDWARDS, JE
不同病因的门静脉高压患者可能会出现肺动脉高压。在目前的尸检研究中，对 12 名肺动脉高压和门静脉高压并存的患者的肺和肝组织进行了研究。 10 名患者存在丛源性肺动脉病，其中 7 名患者同时存在血栓栓塞病变。一名患者有孤立的内侧肥大，这可能是丛源性类别的早期阶段，而一名受试者观察到孤立的血栓栓塞性肺血管疾病。 7 名患者的肝脏疾病符合酒精性肝硬化，4 名患者患有隐源性肝硬化，1 名患者患有肝外门脉高压但无肝硬化。测定血小板计数的所有 10 名患者均出现血小板减少症。这项研究表明，与门静脉高压相关的肺动脉高压在组织学检查中通常具有丛源性表现。然而，血栓形成（无论是栓塞还是原位）也可能导致血管阻塞。
Patients with portal hypertension of varying etiology may develop pulmonary artery hypertension. In the present autopsy study, pulmonary and hepatic tissue was studied in 12 patients in whom pulmonary and portal hypertension coexisted. Plexogenic pulmonary arteriopathy was present in 10 patients, 7 of whom had coexistent thromboembolic lesions. One patient had isolated medial hypertrophy, which may be an early stage in the plexogenic category, whereas isolated thromboembolic pulmonary vascular disease was observed in one subject. Hepatic disease was consistent with alcoholic cirrhosis in seven patients, cryptogenic cirrhosis in four and extrahepatic portal hypertension without cirrhosis in one. Thrombocytopenia was present in all 10 patients whose platelet count was determined. This study suggests that pulmonary hypertension associated with portal hypertension commonly had a plexogenic appearance on histologic examination. However, thrombosis (whether embolic or in situ) may also contribute to vascular obstruction.