Influence of Aging and Environment on Presentation of Infection in Older Adults
Influence of Aging and Environment on Presentation of Infection in Older Adults
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DOI：
10.1016/j.idc.2017.07.017
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发表时间：
2017-12-01
影响因子：
4.4
通讯作者：
Jump, Robin L. P.
中科院分区：
文献类型：
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作者：
El Chakhtoura, Nadim G.;Bonomo, Robert A.;Jump, Robin L. P.
在老年人中，病理生理、临床和环境因素都会影响感染的表现。我们探讨了年龄相关的变化如何影响这一人群感染的表现和评价。具体的主题包括免疫衰老，与年龄相关的器官特异性生理变化和脆弱。我们还描述了影响老年人感染风险和表现的临床因素，包括体温调节、认知能力下降和营养不良。最后，我们讨论了老年人居住的环境对感染的临床评价的影响。了解所有这些变化的影响可能有助于预防，早期识别和治疗老年人感染。
In older adults, pathophysiologic, clinical, and environmental factors all affect the presentation of infections. We explore how age-related changes influence the manifestation and evaluation of infections in this population. Specific topics include immunosenescence, age-related organ-specific physiologic changes, and frailty. We also describe clinical factors influencing infection risk and presentation in older adults, including temperature regulation, cognitive decline, and malnutrition. Finally, we discuss the influence of the setting in which older adults reside on the clinical evaluation of infection. Understanding the influence of all these changes may facilitate the prevention, early recognition, and treatment of infections in older adults.