The transcription factor network in Th9 cells.
The transcription factor network in Th9 cells.
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DOI：
10.1007/s00281-016-0600-2
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发表时间：
2017-01
影响因子：
9
通讯作者：
Kaplan MH
中科院分区：
文献类型：
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作者：
Kaplan MH
T辅助细胞亚群的发育需要活化的T细胞，其响应于极化细胞因子环境，导致转录因子的活化和表达。亚群特异性转录因子结合并诱导特异性效应细胞因子的产生。Th 9细胞表达IL-9并在TGFβ、IL-4和IL-2存在下发育。这些细胞因子中的每一种都激活Th 9分化和IL-9产生所需的信号传导途径。在这篇综述中，我总结了目前所了解的信号通路和转录因子，促进Th 9的遗传程序，提供了一些角度整合的信号调节IL 9基因和支配其他Th 9相关基因的表达。我强调了小鼠细胞中的实验如何建立了一个在人类T细胞中保守的转录网络，并为更详细地了解Th 9细胞发育和功能定义下一个重要问题奠定了基础。
The development of T helper cell subsets requires activated T cells that respond to a polarizing cytokine environment resulting in the activation and expression of transcription factors. The subset-specific transcription factors bind and induce the production of specific effector cytokines. Th9 cells express IL-9 and develop in the presence of TGFβ, IL-4, and IL-2. Each of these cytokines activates signaling pathways that are required for Th9 differentiation and IL-9 production. In this review I summarize what is currently understood about the signaling pathways and transcription factors that promote the Th9 genetic program, providing some perspective for the integration of the signals in regulating the Il9 gene and dictating the expression of other Th9-associated genes. I highlight how experiments in mouse cells have established a transcriptional network that is conserved in human T cells, and set the stage towards defining the next important questions for a more detailed understanding of Th9 cell development and function.