Plasma lipid peroxidation products and antioxidant enzyme activities in patients with type 2 diabetes mellitus
Plasma lipid peroxidation products and antioxidant enzyme activities in patients with type 2 diabetes mellitus
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DOI：
10.1007/s005920200029
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发表时间：
2002-09-01
影响因子：
3.8
通讯作者：
Bayraktar, N
中科院分区：
文献类型：
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作者：
Turk, HM;Sevinc, A;Bayraktar, N
糖尿病与硫代巴比妥酸反应物质（TBARS）的显著增加有关，TBARS被认为是内源性脂质过氧化的指标。人体有一个复杂的抗氧化防御系统，可以防止自由基链反应的启动。我们测定了血浆TBARS水平、超氧化物歧化酶（SOD）和过氧化氢酶（CAT）活性，并比较了它们与糖尿病代谢控制和糖尿病微血管病变的关系。64例2型糖尿病患者（19例男性），年龄52.35 ± 9.31岁，入组本研究。36名健康受试者（12名男性），年龄为51.02 ± 7.01岁，组成对照组。与对照组相比，糖尿病组TBARS水平和SOD活性升高（p
Diabetes is associated with a significant increase in thiobarbituric acid reactive substances (TBARS) which are considered as an index of endogenous lipid peroxidation. The human body has a complex antioxidant defense system that prevents the initiation of free radical chain reactions. We measured plasma TBARS levels, superoxide dismutase (SOD) and catalase (CAT) activities and compared their relation to the metabolic control of diabetes and diabetic microangiopathy. Sixty-four patients (19 men), aged 52.35 +/- 9.31 years with type 2 diabetes mellitus were included in the study. Thirty-six healthy subjects (12 men), aged 51.02 +/- 7.01 years formed the control group. TBARS levels and SOD activity were elevated in the diabetic group when compared with the control group (p