Overcoming Therapeutic Resistance of Bone Sarcomas: Overview of the Molecular Mechanisms and Therapeutic Targets for Bone Sarcoma Stem Cells.
Overcoming Therapeutic Resistance of Bone Sarcomas: Overview of the Molecular Mechanisms and Therapeutic Targets for Bone Sarcoma Stem Cells.
复制标题
克服骨肉瘤的治疗性：骨肉瘤干细胞的分子机制和治疗靶标的概述。
DOI：
10.1155/2016/2603092
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发表时间：
2016
影响因子：
4.3
通讯作者：
Ozaki T
中科院分区：
文献类型：
--
作者：
Fujiwara T;Ozaki T
骨肉瘤是一种异质性恶性肿瘤，表现出临床、组织学和分子异质性。近年来多模式治疗的进展逐渐改善了患者的预后，然而，耐药性和远处转移仍然是未解决的临床问题。最近的研究表明，骨肉瘤中存在癌干细胞样细胞（CSCs），其代表具有高成瘤能力的肿瘤细胞亚群。CSC的特征包括肿瘤和转移形成潜力和耐药性，这是导致骨肉瘤患者预后不良的原因。因此，阐明肿瘤干细胞的分子机制和确定治疗靶点，将有助于骨肉瘤的新的治疗策略和改善患者的预后。本文概述了骨肉瘤干细胞和临床前分析的积累知识，以克服其致命的表型，除了讨论其潜在的新的治疗骨肉瘤。
Bone sarcomas are heterogeneous malignant tumors that exhibit clinical, histological, and molecular heterogeneity. Recent progress in their multimodal treatment has gradually improved patient prognosis; however, drug resistance and distant metastasis remain unresolved clinical problems. Recent investigations have suggested the existence of cancer stem-like cells (CSCs) in bone sarcomas, which represent a subpopulation of tumor cells with high tumor-forming ability. The hallmarks of CSCs include tumor- and metastasis-forming potential and drug resistance, which are responsible for poor prognoses of bone sarcoma patients. Therefore, elucidation of the molecular mechanisms of CSCs and identification of therapeutic targets could contribute to novel treatment strategies for bone sarcomas and improve patient prognosis. This paper provides an overview of the accumulating knowledge on bone sarcoma stem cells and preclinical analyses to overcome their lethal phenotypes, in addition to a discussion of their potential for novel therapeutics for bone sarcomas.