Partnering up for cardiac hypertrophy.
Partnering up for cardiac hypertrophy.
复制标题
合作治疗心脏肥大。
DOI：
10.1161/01.res.0000221823.31424.47
复制
发表时间：
2006
影响因子：
20.1
通讯作者：
Leinwand,LeslieA
中科院分区：
文献类型：
--
作者：
Konhilas,JohnP;Leinwand,LeslieA
The heart must adapt its mechanical activity to the prevailing hemodynamic demands. When an increased demand is brought about by sustained stimuli such as growth and development, pressure overload, or mutations in sarcomeric proteins, the heart will typically undergo an increase in size caused by myocyte hypertrophy. Underlying this hypertrophic response is the coordinated interaction of distinct signaling modules capable of transmitting and executing modifications in gene expression that lead to alterations in myocyte physiology and long-term cardiac adaptation. 1One of the more intriguing characteristics of the hypertrophic response is that despite the ability of a wide variety of both pathologic and physiologic stimuli to induce cardiac hypertrophy, distinct cytoplasmic signaling cascades that initiate changes in gene expression converge on a common set of nuclear factors. These factors will then transactivate or repress cardiac genes through cis-regulatory elements. One of these transcription factors, myocardin, that appears to be capable of relaying hypertrophic signals to the genome is the subject of the studies performed by Xing et al2 detailed below.
