Effects of intestinal microbiota on anxiety-like behavior
Effects of intestinal microbiota on anxiety-like behavior
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DOI：
10.4161/cib.15702
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发表时间：
2011-07
影响因子：
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通讯作者：
Karen A Neufeld;N. Kang;J. Bienenstock;J. Foster
中科院分区：
文献类型：
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作者：
Karen A Neufeld;N. Kang;J. Bienenstock;J. Foster
在出生后立即获得肠道微生物群对健康和福祉不可或缺的许多免疫和代谢系统的发育和功能具有决定性影响。最近的研究表明，肠道微生物群的存在调节了下丘脑-垂体-肾上腺（HPA）轴活动的设定点。1因此，我们试图研究无菌（GF）小鼠中是否存在其他脑功能变化，如行为改变，如果存在，将这些与正常肠道微生物群小鼠的行为进行比较。我们最近的论文显示，与常规饲养的无特定病原体（SPF）小鼠相比，成年GF小鼠在高架十字迷宫（EFL）中的焦虑样行为减少。2在这里，我们展示了我们接下来用SPF粪便定殖成年GF小鼠时收集的数据，从而引入正常的肠道微生物群，然后重新评估焦虑样行为。有趣的是，在GF小鼠中观察到的抗焦虑行为表型在SPF肠道微生物群定植后持续存在。这些数据表明，肠-脑相互作用对应激系统的中枢神经系统发育很重要，并且可能存在一个关键窗口，在此之后微生物群和免疫系统的重建不会使行为表型正常化
The acquisition of intestinal microbiota in the immediate postnatal period has a defining impact on the development and function of many immune and metabolic systems integral to health and well-being. Recent research has shown that the presence of gut microbiota regulates the set point for hypothalamic-pituitary-adrenal (HPA) axis activity.1 Accordingly, we sought to investigate if there were other changes of brain function such as behavioral alterations in germ free (GF) mice, and if so, to compare these to behavior of mice with normal gut microbiota. Our recent paper showed reduced anxiety-like behavior in the elevated-plus maze (EPM) in adult GF mice when compared to conventionally reared specific pathogen-free (SPF) mice.2 Here, we present data collected when we next colonized the adult GF mice with SPF feces thereby introducing normal gut microbiota, and then reassessed anxiety-like behavior. Interestingly, the anxiolytic behavioral phenotype observed in GF mice persisted after colonization with SPF intestinal microbiota. These data show that gut-brain interactions are important to CNS development of stress systems and that a critical window may exist after which reconstitution of microbiota and the immune system does not normalize the behavioral phenotype