Effects of a 1-Year Exercise and Lifestyle Intervention on Irisin, Adipokines, and Inflammatory Markers in Obese Children
Effects of a 1-Year Exercise and Lifestyle Intervention on Irisin, Adipokines, and Inflammatory Markers in Obese Children
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DOI：
10.1002/oby.20739
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发表时间：
2014-07-01
期刊：
影响因子：
6.9
通讯作者：
Mantzoros, Christos S.
中科院分区：
文献类型：
--
作者：
Blueher, Susann;Panagiotou, Grigorios;Mantzoros, Christos S.
目的：运动改善体重状况和新陈代谢。鸢尾素是一种新型肌因子，可能参与代谢功能的调节。评估了为期 1 年的运动和饮食生活方式干预对鸢尾素、脂肪因子（瘦素、脂联素、抵抗素）和炎症标记物（C 反应蛋白 (CRP)、可溶性肿瘤坏死因子受体 II (sTNFR-II)）的影响，并在肥胖儿童中对鸢尾素水平的预测因子进行了表征。方法：对完成该计划的 65 名肥胖儿童（7-18 岁）在基线和随访时评估参数年龄，54% 男孩）。结果：项目完成后，人体测量和代谢参数得到改善，基线为 111.0 +/- 8.0 ng ml(-1)，干预后增加 12% [6%, 17%]，P = 0.00003。没有证据表明不同性别和不同年龄的鸢尾素水平存在差异。此外，干预后鸢尾素的变化与 BMI-SDS、脂肪因子或炎症标志物的下降无关（Delta 5.3 ng ml(-1), [3.2, 6.3], P = 10(-7)）。结论：为期 1 年的生活方式干预计划与人体测量和代谢参数的改善相关。肥胖儿童的鸢尾素水平升高。
Objective: Exercise improves weight status and metabolism. Irisin, a novel myokine, may be involved in the regulation of metabolic function. The effect of an exercise and dietary lifestyle intervention for 1-year on irisin, adipokines (leptin, adiponectin, resistin) and inflammatory markers (C-reactive protein (CRP), soluble tumor necrosis factor receptor II (sTNFR-II) was evaluated, and predictors of irisin levels were characterized in obese children.Methods: Parameters were assessed at baseline and at follow-up for 65 obese children who completed the program (7-18 years, 54%boys). Their relation to weight status and metabolic risk was analyzed.Results: Anthropometric and metabolic parameters improved after completion of the program. Circulating irisin levels at baseline were 111.0 +/- 8.0 ng ml(-1) and increased after the intervention by 12% [6%, 17%], P = 0.00003. There was no evidence for differences in irisin levels between genders and across age. Moreover, changes in irisin did not correlate with those in BMI-SDS, adipokines or inflammatory markers. Leptin decreased after the intervention (Delta 5.3 ng ml(-1), [3.2, 6.3], P = 10(-7)). Anthropometric measures were significantly associated with leptin and inflammatory markers.Conclusions: A 1-year long lifestyle intervention program is associated with improvement in anthropometric and metabolic parameters and leads to an elevation in irisin levels in obese children.