Regional fat distribution in women and risk of cardiovascular disease
Regional fat distribution in women and risk of cardiovascular disease
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DOI：
10.1093/ajcn/65.3.855
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发表时间：
1997-03-01
影响因子：
7.1
通讯作者：
Treuth, MS
中科院分区：
文献类型：
--
作者：
Williams, MJ;Hunter, GR;Treuth, MS
技术的改进使得能够更精确地测量区域脂肪分布，并且还提供了对各种脂肪库进行系统评估的机会，包括腹内脂肪组织（IAF），皮下脂肪组织（SAF），躯干脂肪，手臂脂肪和腿部脂肪。这项研究的目的是确定哪些脂肪分布变量（臂脂肪、腿脂肪、躯干脂肪、IAF或SAF）可能与心血管（CVD）危险因素[血清三酰甘油、血清胆固醇、高密度脂蛋白（HDL）胆固醇、HDL（2）胆固醇、HDL（3）胆固醇、低密度脂蛋白（LDL）胆固醇、极低密度脂蛋白（VLDL）胆固醇、校正年龄、绝经状态和其他脂肪分布变量后，女性的VLDL（3）胆固醇、脂蛋白（a）、收缩压和舒张压]。对224名（138名绝经前和86名绝经后）年龄范围为17至77岁的白色女性进行了采样。体脂百分比范围为8.8%至48.1%，IAF横截面范围为9.2至335 cm（2）。计算简单的零线性相关和偏相关。IAF和躯干脂肪始终与CVD风险因素呈正相关，而腿部脂肪始终与CVD风险呈负相关，表明IAF和躯干脂肪可能会增加女性患CVD的风险。
Improvements in technology have allowed more precise measurements of regional fat distribution and also present the opportunity to make a systematic evaluation of the various fat depots, including intraabdominal adipose tissue (IAF), subcutaneous adipose tissue (SAF), trunk fat, arm fat, and leg fat. The purpose of this study was to determine which of the fat distribution variables (arm fat, leg fat, trunk fat, IAF, or SAF) may have independent relations with cardiovascular (CVD) risk factors [serum triacylglycerol, serum cholesterol, high-density-lipoprotein (HDL) cholesterol, HDL(2) cholesterol, HDL(3) cholesterol, low-density-lipoprotein (LDL) cholesterol, very-low-density-lipoprotein (VLDL) cholesterol, VLDL(3) cholesterol, lipoprotein(a), and systolic and diastolic blood pressure] in women after adjusting for age, menopause status, and other fat-distribution variables. Two hundred twenty-four (138 premenopausal and 86 postmenopausal) white females ranging in age from 17 to 77 y were sampled. Percentage body fat ranged from 8.8% to 48.1% and IAF cross sections ranged from 9.2 to 335 cm(2). Simple zero-linear correlations and partial correlations were calculated. IAF and trunk fat were consistently positively related to CVD risk factors, whereas leg fat was consistently negatively related to CVD risk, indicating that IAF and trunk fat may put women at increased risk of developing CVD.