Influenza viruses and mRNA splicing: doing more with less.
Influenza viruses and mRNA splicing: doing more with less.
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DOI：
10.1128/mbio.00070-14
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发表时间：
2014-05-13
期刊：
影响因子：
6.4
通讯作者：
Rosa-Calatrava M
中科院分区：
文献类型：
--
作者：
Dubois J;Terrier O;Rosa-Calatrava M
在它们的核复制阶段，流感病毒劫持宿主剪接机制来加工它们的一些RNA片段，即M和NS片段。在这篇综述中，我们提供了一个概述，目前的知识收集流感病毒和细胞剪接体之间的相互作用，特别是侧重于甲型流感病毒（IAV）。这些病毒已经开发出精确的调节机制，以重新分配宿主剪接体来改变宿主细胞表达，并使特定剪接病毒产物在整个感染过程中得到最佳表达。此外，IAV片段进行剪接显示高水平的相似性与人类的共识剪接位点和它们的病毒转录本显示值得注意的二级结构。序列比对和一致性分析，沿着最近发表的研究，表明病毒剪接位点序列和结构的保守和进化，以改善对宿主的适应。总之，这些结果强调了IAV能够很好地适应宿主的剪接机制，进一步的研究可能有助于更好地了解剪接调节病毒复制，宿主范围和发病机制。
During their nuclear replication stage, influenza viruses hijack the host splicing machinery to process some of their RNA segments, the M and NS segments. In this review, we provide an overview of the current knowledge gathered on this interplay between influenza viruses and the cellular spliceosome, with a particular focus on influenza A viruses (IAV). These viruses have developed accurate regulation mechanisms to reassign the host spliceosome to alter host cellular expression and enable an optimal expression of specific spliced viral products throughout infection. Moreover, IAV segments undergoing splicing display high levels of similarity with human consensus splice sites and their viral transcripts show noteworthy secondary structures. Sequence alignments and consensus analyses, along with recently published studies, suggest both conservation and evolution of viral splice site sequences and structure for improved adaptation to the host. Altogether, these results emphasize the ability of IAV to be well adapted to the host’s splicing machinery, and further investigations may contribute to a better understanding of splicing regulation with regard to viral replication, host range, and pathogenesis.